@Pinktree, Buprenex is not for inflammation; it's for pain. Since stress plays a part in idiopathic cystitis, it is probably keeping her calm since it's an opiate, thereby helping to keep the bladder from spasming. The Convenia shot helping her may only have been a coincidence. I agree with the vet that the overuse of antibiotics is prevalent and not a good idea, but sometimes they are necessary. Since antibiotics tend to kill off the good flora in the intestines and upset their tummies, I always supplement with a probiotic when one of mine is given antibiotics. It sounds like little Palmer is doing better today! YAY! Please keep us updated.