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Good luck on Sept. 7! From what you said in the above post I would have expected your vet to provide you with more reassurance and an explanation. Is Ed on 1.25 mg twice a day or 2.5 mg twice a day? When you bring Ed in for bloodwork you may want to write down all your questions beforehand so you can discuss them with him. If for any reason you feel apprehensive about the answers you are receiving or lack of them you may want to consider a second opinion. All the best of luck and please keep us posted.My vet didn't really say anything about reducing the dose or stopping; he just agreed to let me try the transdermal. We re-set to 2.5mg on Aug 14, he has blood work scheduled for Sept 7.