Some advice required, Meloxicam or Prednidale my cat with CKD.

Al_Pickles

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Hello all,

Arron here, firstly thank you for taking your time to read my query, I’ll start off by saying I totally understand the use of both of the above medications simultaneously is a complete no no.

I’ll try to summarise my darling little boy’s situation, he’s a Siamese Apricot Point who goes by the name of Mia. (He has a feminine name I know haha). So he’s 17 and has had CKD and for a few years now and he is currently at the beginning of stage 3.

Me and my girlfriend do everything we can to care for him in the best way. He is a wonderful cat, so intelligent, full of energy with an amazing appetite, he’s on Royal Canine renal wet food, and we feed him little and often, roughly around 7-8 times a day adding plenty of additional water, as well as renal support additives such as Ipakatine once daily and so on and he doesn’t leave a morsel.

I’ll just add he has some sort of medication in almost every meal, he has Amodip to manage his high blood pressure, a small amount of Gabapentin in the morning and evening to manage potential dental pain, Ipakatine, Cystease, and ongoing Meloxicam these last few months. I know this sounds like a lot of things but he’s been on this cocktail for a long time, he has regular blood tests, check ups and since the introduction of all these things they have done absolute wonders for our boy.

He had some real trouble with his mouth about 1.5 years ago, he caught a terrible infection a while back and underwent a dental (in which he stopped breathing twice) to remove all his last remaining back teeth (there weren’t that many left) and he just has his fangs remaining.

Less than a year later (this year) we began to notice similar signs again of mouth issues but far worse, dribbling, choking on food sometimes, he looked very down and couldn’t stand having his mouth touched. We took him once again and the vet said he would greatly benefit by having his fangs removed, however, he did mention it may not make a difference so before anything is decided he must absolutely take a closer look via sedation, we were quite concerned about this op as it sounds brutal but it’s all about quality of life of course. He went for the op a few months ago and stopped breathing just under sedation, the vet decided there’s no way it would be safe to proceed with the op as he’s so unstable and the last thing he’d want to do is ‘kill him in action’, he took some samples for a biopsy.

The biopsy revealed he had two different types of bacterial infections, ulcers in his throat and also revealed he has Calicivirus, which of course is likely a huge contributing factor as to his ongoing mouth issues. I felt so terribly sorry for him and naturally very guilty. I wasn’t aware just how bad it was and how awful he must have felt. By the way I’ll just reveal what an incredible appetite he has, despite all of the above, he still never turned down a meal.

So a few months ago he went on a course of antibiotics, the results were astonishing! Brought him right back to us, sorted all his ulcers, the dribbling, mouth sensitivity and he went back to rubbing his little cheeks on everything!

Now I arrive at the present, so to manage the inflammation of his gums and overall well-being the vet suggested an ongoing meloxicam dosage every other day of 3.5kg/mg (going by the supplied weight measurement syringe). I of course did plenty of reading regarding the use of this drug with CKD and decided to give it a whirl after much deliberation and stressful pondering.

So I started off at a lower dosage of 2kg on the syringe measurement every other day and have been doing this since the end of October. I can’t possibly describe how incredible this drug has been for Mia, physically it’s like he’s reverted to 4 year old. His agility and movement are outstanding once again, he went from taking one step at a time on the stairs to sprinting up them. He has gone back to getting ‘the zoomies’ which he stopped doing for several years and now leaps on beds with ease. It also brought back his curiosity, improved his bowel movements (nice and solid). It has done wonders for his inflammation and he can wolf his food down freely, and he once again is so very curious. Truly it’s been one of the best decisions we have made. I understand there’s risks but as I have stated, it’s all about quality of life at this point.

One last bit of history before I finally move on to the question at hand, a couple of years ago Mia’s weight dropped to 2.3kg, he was very underweight, and has just got a diagnosis of CKD, when discovered he was at stage 2 (he has only moved one stage in the past 2 years) the vets were very concerned, saying it’s possibly cancer and all sorts of things. I was aware he was so disineresred in his food, and he had no other symptoms and I just believed he had so much more to give. At this time we completely changed his diet, switched to royal canine renal, constantly changing up the flavour every meal with their beef, chicken and fish flavours and he now weighs over 5kg. The vets we’re so impressed we manage to get him to gain so much weight especially with CKD, he’s maintained this weight for the past two years now.

Right, thank you so much for everyone who’s got through that hefty slog of a read, the reason I went into such great detail is to hopefully provide some useful info to some other cat owners! Apologies if any of it is incoherent, or contains some dodgy grammar. I’ve awkwardly typed it all on my phone.

Mia is currently doing wonderfully, his energy levels and zest and appetite are superb, he’s always purring and is wonderfully affectionate but there is once again the mouth issue. Recently I noticed another few signs an infection is returning, likely due to Calicivirus. I asked the vet if he could go on another course of antibiotics to nip it in the bud and avoid another ulcer episode, he said it’s best avoided currently to prevent Mia developing a resistance but suggested trying some other things first and if they don’t work we can resort to antibiotics.

So the vet said we could try Mia on prednidale, meaning coming off the Meloxicam which has been so wonderful for him. He required a free day ‘flush out’ period before beginning the prednidale, now his mouth issues currently aren’t bad at all. I assumed I’d just be given some antibiotics. Anyway I have the prednidale, yet I am yet to begin with these. The choice is, longterm meloxicam, or longterm prednidale if they work wonders, of course I’m not sure how he’ll do on prednidale, he already has an insatiable appetite, if it gets boosted he’ll
think of nothing else! Then again I can keep him on meloxicam, up that dosage a tad as I am still under the suggested doasage and then if his mouth issues get worse I can resort to the antibiotics also, buying more time before having to use them to prevent resistance. So here’s the question!

What’s easier on the kidneys? Meloxicam or Prednidale?

Lastly, I very much trust my vet, he has helped Mia time and time again as well as performing his dental surgeries with wonderful results. I guess I’m just asking these questions as I’m really not sure what choice to make this time.

Thank you to everyone who read all of that, we adore Mia so very much, we never leave him alone for more than 2.5 hours and base all of our decisions around him and do so with zero resentment, he brings us so much happiness and I want to make the time he has left as happy and comfortable as possible.

Apologies, rather than outright ask a question that may have no genuine answer as to what medication would be friendlier on his kidneys, I should also ask, does anyone have experience with giving a cat with CKD prednidale? As there’s so little info on this situation out there on the net, where as there’s a heck of a lot of discussion and info regarding Meloxicam and CKD.
 

fionasmom

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Search Results for Query: meloxicam
This will help you search out TCS posts about the use of meloxicam. Opinions vary and some members do not use it at all, whereas others have been happy with its effects.
Meloxicam | VCA Animal Hospital.
VCA discussion and cautions
Metacam For Cats: The Pros And Cons Of Meloxicam For Pain Relief – TheCatSite Articles
TCS article

Tanya's Comprehensive Guide to Feline Chronic Kidney Disease - Steroids,Stem Cell Transplants and Kidney Transplants

Tanya's Comprehensive Guide to Feline Chronic Kidney Disease - Everything You Need to Know to Help Your Cat

I have never used Meloxicam, partly because it has never been suggested and have not used pred with a cat with CKD; however, I do see you point in that you are between two possibly questionable options for a CKD cat. Right now you are in the middle of the issue with the mouth infection though and have a couple of options; which option is your vet most strongly suggesting?
 
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Al_Pickles

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Search Results for Query: meloxicam
This will help you search out TCS posts about the use of meloxicam. Opinions vary and some members do not use it at all, whereas others have been happy with its effects.
Meloxicam | VCA Animal Hospital.
VCA discussion and cautions
Metacam For Cats: The Pros And Cons Of Meloxicam For Pain Relief – TheCatSite Articles
TCS article

Tanya's Comprehensive Guide to Feline Chronic Kidney Disease - Steroids,Stem Cell Transplants and Kidney Transplants

Tanya's Comprehensive Guide to Feline Chronic Kidney Disease - Everything You Need to Know to Help Your Cat

I have never used Meloxicam, partly because it has never been suggested and have not used pred with a cat with CKD; however, I do see you point in that you are between two possibly questionable options for a CKD cat. Right now you are in the middle of the issue with the mouth infection though and have a couple of options; which option is your vet most strongly suggesting?
Thank you so much for the reply and advice, as mentioned above, Mia’s been on Meloxicam for 2 months now and it’s had the most incredible and positive affect on his entire well being and of course the inflammation.

The vet suggested switching to the prednidale if I want to as it can be even more beneficial in terms of tackling inflammation, so it could have a wonderful effect on the condition of his mouth. But I’m thinking, perhaps he then wouldn’t feel so good overall, as the Meloxicam has a wonderful effect on his joints.

Mia currently is doing great and it’s just perhaps early small signs of another possible infection so I am just holding off on the prednidale for the time being while I attempt to gather any sort of info on longterm prednidale and CKD. The vet said I can switch to the prednidale and if any issues/side effects I can just stop them and go back to the Meloxicam. So I guess I can trial it but it’s a difficult decision when you feel you’ve got a good thing going currently and not knowing if switching could make him feel even better or worse. (Apologies I meant three day flush out period in my original post, not ‘free day’)
 

mrsgreenjeens

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I just want to say that I read your entire post and think you are doing an amazing job with Mia. Once my last kidney cat lost weight, no matter how much she ate, she never was able to gain that weight back, so kudos to you!

What would happen is you used a different antibiotic this time than last time? Wouldn't that help avoid antibiotic resistance. I do know that certain antibiotics work better than others, but there are five broad spectrum antibiotics available for use in cats, so it might be an option. And I couldn't find much on Prednadale, but I think it's similr to Prednilosone here in the U.S., and did read that it can have an adverse effect on high blood pressure, which Mia has. Just food for thought in case it's the same medication.

Keep us posted on how he does please.
 
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Al_Pickles

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I just want to say that I read your entire post and think you are doing an amazing job with Mia. Once my last kidney cat lost weight, no matter how much she ate, she never was able to gain that weight back, so kudos to you!

What would happen is you used a different antibiotic this time than last time? Wouldn't that help avoid antibiotic resistance. I do know that certain antibiotics work better than others, but there are five broad spectrum antibiotics available for use in cats, so it might be an option. And I couldn't find much on Prednadale, but I think it's similr to Prednilosone here in the U.S., and did read that it can have an adverse effect on high blood pressure, which Mia has. Just food for thought in case it's the same medication.

Keep us posted on how he does please.
Oh thank you so much for reading all of it, I often think we are fortunate he is such a good eater, Mia makes it easy due to his absolute love of food and to get him to take all the medication is a piece of cake. The vet has told me that at some point his weight will start dropping off no matter how much he eats but he’s done so well thus far and we’ve not yet entered that area.

Thanks for the antibiotic advice and thanks so much for looking into any info for me regarding the prednidale, I’ll absolutely suggest the alternative antibiotics if I notice any worsening symptoms soon so we can nip it in the bud.

I did ask the Meloxicam or Prednidale to the vet and staff on my last visit and they were very truthful which I appreciate by saying ‘none of these are good for Kidney’s’, so I guess there’s no real answer but hopefully someone will pop up who used prednidale/prednilosone longterm with CKD. I’m in the UK so perhaps I’d have more luck with the U.S version when searching.

I hope you have a lovely day and I’ll be sure to keep you updated.
 

silent meowlook

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Hi. I personally wouldn't use meloxicam on any cat, let alone a cat with stage 3 renal disease. If you have been using it and saw great improvement, that is great.

Calicivirus is a virus, therefore not treated with antibiotics. Although secondary bacterial infections can be treated with antibiotics. But, if there is a secondary bacterial infection going on or starting up, I would think the last thing you would want to do is treat with prednisolone which will lower the immune system.

Has your cat ever been tested for FELV or FIV? Not suggesting you do it now. Just curious. I truly don't believe it is beneficial to stress cats out with testing of things when the answer won't change the treatment.

You mentioned your cat has high blood pressure. Prednisolone is not recommended for cats with high blood pressure. Allot of things are contraindicated in use with certain diseases but they are used anyway. The veterinarian has to weigh out the pros and cons of the medication and side effects to determine if it is worth it.

I know you said you trust your vet and that is great, but there is also never anything wrong with getting a second opinion from a specialist. Veterinarians do not take offense to this. Or at least they shouldn't. There is just no way for one person to know everything there is about feline medicine when what is known is changing daily. That being said of course you don't want to needlessly stress your cat with extra visits.

Bottom line is, you are already doing something risky in ckd cat, but that is working for you and your cat and makes him feel better. So. why change it? I certainly wouldn't up the dose of Medicam.

There is no easy or complicated answer to your question because there is no way of knowing what will happen or how your cat will respond. I have seen cats on prednisolone with kidney disease before. They go downhill eventually but if that is due to the prednisolone or not, there is no way of knowing.
 
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Al_Pickles

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Hi. I personally wouldn't use meloxicam on any cat, let alone a cat with stage 3 renal disease. If you have been using it and saw great improvement, that is great.

Calicivirus is a virus, therefore not treated with antibiotics. Although secondary bacterial infections can be treated with antibiotics. But, if there is a secondary bacterial infection going on or starting up, I would think the last thing you would want to do is treat with prednisolone which will lower the immune system.

Has your cat ever been tested for FELV or FIV? Not suggesting you do it now. Just curious. I truly don't believe it is beneficial to stress cats out with testing of things when the answer won't change the treatment.

You mentioned your cat has high blood pressure. Prednisolone is not recommended for cats with high blood pressure. Allot of things are contraindicated in use with certain diseases but they are used anyway. The veterinarian has to weigh out the pros and cons of the medication and side effects to determine if it is worth it.

I know you said you trust your vet and that is great, but there is also never anything wrong with getting a second opinion from a specialist. Veterinarians do not take offense to this. Or at least they shouldn't. There is just no way for one person to know everything there is about feline medicine when what is known is changing daily. That being said of course you don't want to needlessly stress your cat with extra visits.

Bottom line is, you are already doing something risky in ckd cat, but that is working for you and your cat and makes him feel better. So. why change it? I certainly wouldn't up the dose of Medicam.

There is no easy or complicated answer to your question because there is no way of knowing what will happen or how your cat will respond. I have seen cats on prednisolone with kidney disease before. They go downhill eventually but if that is due to the prednisolone or not, there is no way of knowing.
Hello, thank you so much for the reply. Yeah I guess there’s no real answer and I do agree with the ‘why change it’ option but I just wanted to get involved with some other cat lovers, as I’m just always trying to do
. Understandably they’re all individuals and there’s no certainty or perfectly mapped out method.

Yeah I’m aware that Calicivirus can’t be cured with antibiotics, it’s just that was interesting to find out he had it as that’s likely what’s contributing to the infections, the vet did inform me that you need to supply immune boosters to your cat at a young age to keep that Calicivirus at bay.

As for FELV, his biopsy tested many many things, also Mia is an indoor cat and we have no other pets, much appreciate the info but I don’t think that’s the case on that one or it would be very unlikely.

As for the Meloxicam, yeah I understand the risks and it wasn’t something we entered into lightly but I think now, even if it took some of his precious time away it’s life changing for him, his quality of life has gone through the roof the past couple months since it’s introduction and that’s what it’s all about for us at this point.

He’s got another blood test in February so I can update you all then with regards to the effects of the Meloxicam on his kidneys at stage 3, the more info out there the better eh.

As for the blood pressure, like Prednidale the Meloxicam can reduce or increase it, he had a blood pressure check recently and it was all wonderfully stable and unchanged.

Thanks again so much for your info and involvement. Have a wonderful day.
 
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Al_Pickles

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Hello, thank you so much for the reply. Yeah I guess there’s no real answer and I do agree with the ‘why change it’ option but I just wanted to get involved with some other cat lovers, as I’m just always trying to do
. Understandably they’re all individuals and there’s no certainty or perfectly mapped out method.

Yeah I’m aware that Calicivirus can’t be cured with antibiotics, it’s just that was interesting to find out he had it as that’s likely what’s contributing to the infections, the vet did inform me that you need to supply immune boosters to your cat at a young age to keep that Calicivirus at bay.

As for FELV, his biopsy tested many many things, also Mia is an indoor cat and we have no other pets, much appreciate the info but I don’t think that’s the case on that one or it would be very unlikely.

As for the Meloxicam, yeah I understand the risks and it wasn’t something we entered into lightly but I think now, even if it took some of his precious time away it’s life changing for him, his quality of life has gone through the roof the past couple months since it’s introduction and that’s what it’s all about for us at this point.

He’s got another blood test in February so I can update you all then with regards to the effects of the Meloxicam on his kidneys at stage 3, the more info out there the better eh.

As for the blood pressure, like Prednidale the Meloxicam can reduce or increase it, he had a blood pressure check recently and it was all wonderfully stable and unchanged.

Thanks again so much for your info and involvement. Have a wonderful day.
*typo fix

Hello, thank you so much for the reply. Yeah I guess there’s no real answer and I do agree with the ‘why change it’ option but I just wanted to get involved with some other cat lovers, as I’m just always trying to do my best for himUnderstandably they’re all individuals and there’s no certainty or perfectly mapped out method.
 
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