I would think that as long as s/he has plenty of room to run and play s/he would be as happy as any other indoor only kitty. I don't know your housing situation, but you could built a cat enclosure on the back of your house. Kind of like a screened in porch, but with the grass still there and things to climb on and play with. Here is a link of some pictures of one of our member's enclosure for her cats. They just love it!