Grapefruit Seed Extract (GSE) (GFSE) part 1

c8rams

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Okay, time to start a 2013 thread on the uses of Grapefruit Seed Extract, sometimes abbreviated GSE (and more recently abbreviated GFSE, so as not to be confused with a totally different compound: grape seed extract).  Whichever abbreviation you use in this thread, please make sure you are writing about this substance: GRAPEFRUIT Seed Extract. 

And that was probably the least complicated part of this post!  
  

I adopted 2 cats, who came from a stress-inducing situation that helped create their immuno-deficiencies. It's likely that vaccinosis compounded the problem. The sicker one will be 2 yrs in December, and has chronic respiratory and pruritic  symptoms that suggest one or more of the following: form of URI, URD, asthma, allergy, parasite, pulmonary/thyroid disease). After 7 and a half months of being on some level of Zithromax, I finished tapering him off 2 weeks ago. His symptoms began to return, and I did a search for ways to help boost kitty immune systems, which led to some very old (2004) threads on GFSE, one of which I attempted to re-start, and which gives the background for this current thread/post:

http://www.thecatsite.com/t/31431/grapeseed-extract-for-cats   (except that the title is an error -- the thread is actually about GrapeFRUIT seed extract) 

As promised, I've been researching, and probably have way more info than anyone needs. I collated most of it into several pdfs, and hope I'm able to / allowed to insert them into this post, or a series of posts on this thread (still pretty new to the forum and finding my way). I also finally developed some opinions I feel confident sharing, but don't want my conclusions to be mistaken for factual advice -- most of the published "claim-type" statements about GFSE are not substantiated with medical research and so few allopathic vets could support giving GFSE internally to cats. Nevertheless, there's a lot of intelligent anecdotal evidence, as well as testimonials, that reinforce the notion that GSE is an effective and successful means of treating various feline illnesses, even virus symptoms. 

I'll give my personal conclusions first:  I am going to use GSE, conservatively, on my cats.  (I am also starting to look into Colloidal Silver). When my sicker cat gets his PCR-URD test, if it comes back positive for herpes, my goal will be to cure/eradicate the herpes. GFSE alone won't accomplish this. Step one for me was nutrition: raw diet/ appropriate supplementation (details in my background post). Once the right nutrition was in place, and the cats were being given the tools to fight their own battle, I was ready for step 2: finding and using the right holistic/natural treatments -- instead of drugs that so often suppress the animal's own immune system in the process of "treating" the symptoms. I stopped using a steroidal eye drop for conjunctivitis, and replaced it with a homemade saline eyewash that uses goldenseal or eyebright to heal the infection / swelling. It works.  And in the wake of the Zithromax, we are hanging in there! But as the runny nose threatens to get worse, and the eye discharge is increasing, I don't want to run straight back to antibiotics if I don't have to (a PCR test might determine otherwise, which will be fine if that's the case). But I do want to give my kitty's immune system a safe, natural boost, if one exists.

This is where GFSE comes in.  It's billed as an anti-microbial and fungicidal that is effective on quite a number of illnesses. Most online content about GSE consists of either bold "claims" (technically, it's not legal for makers of non-FDA approved substances make outright claims, thanks to the big pharma lobby, but who are we kidding -- the language promoting GFSE does everything in its power to suggest claim after medicinal claim), or the stories--some reliable, some not so much--of people who've used GSE. There are also some juried medical articles.

This is where it gets a little messy: sorting out the misunderstandings/misstatements, fine details, formulas and dosages. 

So, though we can't determine a set of "legally true" GSE info, can we at least figure out what's SAFE?  Thankfully, yes. And then some.

Next post: Part 2.  

Argh, it's 4:30 a.m.  -- time to rally!
 
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c8rams

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Grapefruit Seed Extract  (GSE) (GFSE)  --  Part 2

There are 2 liquid formulations of GFSE on the market. The difference is in the concentration of GFSE. 

The stronger formula is known as "Citricidal," which is a trademark, and it's made by a company of the same name. It's a commercial preparation that uses 60% GFSE and 40% Glycerin.  

The weaker formulation is designed for individual, human use, and is made by a company called "Nutribiotic" (registered name). The concentration is 33% GFSE, and 67% Glycerin. Nutribiotic calls this product, "The Original GSE."

Here's the first catch: Nutribiotic also now markets a small container of the commercial strength Citricidal for individual use. They call it "Maximum GSE."

NutriTeam is the professional website that markets/sells and provides the most content about GFSE, including use and dosage instructions.  When the NutriTeam site uses the words “Nutribiotic” or “GSE,” it is almost always referring to the lower concentration of grapefruit seed extract (33%).  When it talks about “Citricidal,” it means the extremely acidic and concentrated formula of 60% GSE.

Most recommendations for human/animal/internal use involve the 33% concentration.

Even though there IS a statement about how to dilute the Citricidal concentration with more water for internal use, it's practically impossible to dilute for cats. I now have both formulas, and please know that, even diluted, the taste of Citricidal is horribly bitter and highly detectable. My cats won’t touch Citricidal, even at extreme dilutions, and I’ve tasted it and can see why: dilution with water isn’t sufficient. Glycerin is the ingredient that offsets the bitterness of GSE. So for cats, imho, best to stick with the 33% product (aka “The Original GSE”). Even with the Original GSE product, my inclination would still be to use a high dilution, and give it  more frequently if necessary. 

Only NutriTeam offers a dosage statement for animals (NutriBiotic does not). The statement: 

For External Use (skin fungi, parasites, or bacterial diseases of the skin):

Mix 50 to 100 drops of Nutribiotic[emoji]174[/emoji] liquid extract in a quart of water, and spray on the infected area. This same dilution can be used as a general antiseptic for cages, stalls, or any other contact areas. No need to rinse or remove residue of GSE. NutriBiotic liquid GSE can also be mixed into virtually any topical preparation, like shampoo, flea-dip, cat litter, bedding, etc.

For Internal Use:

The rule of thumb for gastrointestinal disorders in pets, including bacterial, fungal, parasitic, or viral, is to use one drop of liquid concentrate or 10 milligrams of powder extract per 10 pounds (5kg) of live weight. Use only one-third if using the "professional-strength" concentrate (Citricidal[emoji]174[/emoji]). This can be administered once a day, or in case of known infection, up to three to five times per day. Alternately, Citricidal or NutriBiotic liquid can be injected into the water supply to provide a general level of protection, and then treat infected animals more aggressively. 

Next up: Part 3. More details.  Problematic aspects of claims made about GFSE, and why it's easy to (mistakenly) assume those claims apply equally to humans and animals.

But first, some sleep/work.  This may be a long-ish break.
 

mstyles

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Looking forward to post #3. :)

I really want to do GSE for our kitties, but am hesitant about its possible interactions with meds they are already on. I know that GSE is different than actual grapefruits/grapefruit juice, but doesn't it come from the same place? I have always read that you should not eat grapefruits/drink the juice when taking antibiotics...something about the fact that grapefruits can increase the concentration of the medicine in your system which can of course be toxic. Gelato, who likely has herpes and definitely has mycoplasma felis diagnosed by a culture (the respiratory kind, which is different than mycoplasma haemofelis, the infectious anemia kind) is currently on doxycycline. Cooper, who now also has a watery eye (so I'm guessing got herpes from Gelato), is on prednisolone for IBD. I really worry about grapefruit seed extract interacting with the doxycycline or the prednisolone. I just can't find a lot of info out there about that and possible interactions. 
 
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