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alternative for Propulsid/cisapride?

post #1 of 8
Thread Starter 

Harriet, one of the cats at my job, has been on Propulsid (cisapride) for years, along with lactulose.  I had been getting her cisapride from her vet, 10 mg twice a day.  My office just moved in June and the cats went to their new vet two weeks ago.  That vet only had 5 mg cisapride.  He also told me that now it's nearly impossible to get any more due to the FDA.  He said that some humans have been taking the veterinary supply for themselves (it was taken off the market for people years ago).  I don't know what I'm going to do when her supply runs out.  She's only getting half her usual dose.  The vet said there was another drug (Reglan?) but that it doesn't work as well.  Does anyone have a cat on Reglan?  Was your cat previously on Propulsid?  Is there any other option?

 

Some years ago I noticed Harriet going from one litter box to the next many times throughout the day, but she didn't produce anything.  After a couple of days and no stool I took her to the vet.  The vet was useless and she returned 5 times in the next couple of weeks before I took her somewhere else.  She's been on Propulsid & lactulose ever since.  The second vet said that for whatever reason she had gotten constipated and it might have stretched her colon (? not sure what part it was) and it formed a little bulge or pocket, and now all of her stool tends to catch in that area and builds up because she's unable to move it through herself.  That's what the Propulsid is for, plus lactulose to soften the stool.

 

Her stools tend to be fat and she doesn't go every day,  She also will poop on the floor if she's having trouble.  We have a large cage (from my boss' Labs) and I usually shut her in there with her box & food/water if she hasn't had a bowel movement in 24+ hours.  If she poops before I leave work, she's set free.  Otherwise she spends the night in the cage.  She ends up in the cage overnight maybe twice a week.  Because she lives in a retail store, we can't have her going on the floor.

post #2 of 8
Quote:
Originally Posted by poodlebone View Post

...

Some years ago I noticed Harriet going from one litter box to the next many times throughout the day, but she didn't produce anything.  After a couple of days and no stool I took her to the vet.  The vet was useless and she returned 5 times in the next couple of weeks before I took her somewhere else.  She's been on Propulsid & lactulose ever since.  The second vet said that for whatever reason she had gotten constipated and it might have stretched her colon (? not sure what part it was) and it formed a little bulge or pocket, and now all of her stool tends to catch in that area and builds up because she's unable to move it through herself.  That's what the Propulsid is for, plus lactulose to soften the stool.

...

 

 

 

Hello poodlebone, sounds like Harriet has chronic constipation/megacolon (when the vet told you the constipation stretched her colon).  My cat has the same condition, for years now.  We've been through the same, tried Lactulose, Cicipride (Propulsid), with no consistent results .. what has helped finally for us was not cicipride or lactulose, but MIRALAX, I give him 1/2 teaspoon every other day, it has been a lifesaver for him, look into it, there are quite a few threads here..

(ps let her out of cage for goodness sakes, poop can be cleaned off the floor, she is sad sitting in a cage!!)

post #3 of 8
Thread Starter 

Last year the vet did recommend Miralax.  She hasn't been getting it every day but if she doesn't go in two days she gets it.  She also gets it on Sundays because nobody at work is willing to give her pills or liquid, but mixing something into her food is easy.

 

As for letting her out of the cage, it is a problem because she's in a store.  Customers usually don't enjoy shopping someplace that has poop on the floor.  Putting her in the cage lets her know what she's supposed to do, and most of the time she does go withing 10 minutes of getting shut in.  Since I know she doesn't go every day, if she goes on Day 1 I don't worry about Day 2.  If by the end of Day 2 she hasn't gone, she goes to the cage.  Also, I leave earlier than some of my co-workers and they're instructed to check the box before leaving to let her out if she's gone.
 

post #4 of 8

IVE JUST GONE THROUGH THIS WITH MY CAT.... THEY WANTED TO PUT HER DOWN BECAUSE THEY THOUGHT SHE HAD A MASS IN HER RECTUM AREA... I LEFT THE VET AND TOOK HER TO A SPECIALIST WHERE THEY DID AN OSTIPATION..... MY CAT IS ON THE CIPASIDE AND A STOOL SOFTNER.....SHE IS GOING REGULARLY.... AFTER SOME RESEARCH THOUGH I HAVE ADDED SOME CANNED PUMPKIN TO HER WET FOOD..... SHE IS GOING ON A REGULAR BASIS AND THINGS SEEM TO BE MOVING ALONG.... TRY SOME CANNED PUMPKIN IN THE FOOD.

post #5 of 8

You can still get Cisapride from a compounding pharmacy. I just reordered this medication from my local compounding pharmacy.  Or you an check with one of the mailorder compounding pharmacies like Roadrunner.

post #6 of 8

Have you tried any diet changes? I know many people have treated constipation and mega colon with a combo of diet changes and laxatives and miralax seems like the most popular. Here are some good threads to read through on the topic (http://www.thecatsite.com/t/205398/diet-to-manage-megacolon) and (http://www.thecatsite.com/t/262510/constipation-issues). The megacolon thread is a really interesting one with some great information- good luck!

post #7 of 8

My rescue cat came to me literally nearly dead, with multiple issues...a huge abscessed snake bite causing an open wound from her rib cage to the base of her tail, infested with maggots. Her digestive issues are not just the type usually described as mega colon, but include pelvic injury (probably from a car) which also broke both her back legs, never set, healed incorrectly.  She actually is shaped like the pointed end of a football, and the constriction causes her stool to become hard for her to pass.  She is on Cisapride, lactulose, pumpkin, Miralax and daily sub-Q fluids to assure sufficient fluids to her intestines.  I still have to be vigilant to prevent stool from becoming caught at the end of her tract and causing a hard obstruction.  I think we have made as many changes to her diet as are possible. 

post #8 of 8

Like all of you I have been through the same thing. I have a three year old orange tabby who had to go into the vet 3 times for constipation. It broke my heart seeing him trying to strain to poo. The Vet put him on Cisapride and he got bound up again. After the second visit he was put on laculose as well. For a while it worked wonders on him before his stool became TOO runny. Now he is on the same does of cisapride and laculose as needed. He has gained his weight back and looks as handsome as ever. I would recommend keeping them on the cisapride. I know it costs a lot. We are paying a $157 for one bottle that lasts 4 months but it is worth it.

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