Yes, they must be handled now, before they get any older and learn to mistrust humans. Offer them food and strokes so they get used to humans. Mama will also show them that not all humans are bad. Mama will have to be spayed soon or she will add to the population, I have had a new litter born less tahn 70 days after teh first! More than 17 kittens in one year from a single mother.
I pray you can find homes for them all, that is really no kind of life. Cars, dogs and nasty mean people are a constant threat. They are absolutely adorable! Keep us posted!
I am offering them strokes but not sure any food can be offered at this age. I am also making sure that I visit them without mama knowing. She is a stray cat and doesn't really trust humans and has only recently started to be comfortable around me.