I adopted a three legged cat, Trinity, shortly after her amputation, back left leg. She doesn't seem to mindd and has adapted well. She has a little trouble jumping onto high things, like the counter and such. But she doesn't mind being picked up to help her. She walks with a limp, or a hop really, but she runs like a pro. I think she is a better runner then walker. She loves to chase her tail and she does it on mher back cause she can't run in a cirle without falling over, but I think her missing leg makes it easier to catch her tail. The olny warning I saw on the internet was to watch her weight cause it puts extra stress on the other limbs. The funniest thing to watch is when she is "scratching" her chin or ear with her missing leg. The little stump twichted ans she makes this face like she can feel the scratching. I always ask her, "what are you scratching? An imaginary itch with you imaginary foot?"