It's genetically possible. Japanese Bobtail cats have a higher frequency of non-white odd-eye cats (seen red tabbies with odd eyes).
One of my first household pet cats I showed was a stunning black/white odd-eye (she was perfectly marked with deep blue and deep green eye color). She won many many ribbons and Morris trophies over the years. She was a street cat (my aunt told me about her as a kitten) and lived to be 18 yrs old.
Never seen another like her. I do know of one HHP exhibitor was so jealous she searched the shelters for years to find one like her (never did - but did find a nice black cat with blue eyes).