My cat has lost its vitality for the last couple of days. She has lost weight, and no longer wants to go outside. She is still eating her food and drinking her water. She is very quiet, and usually just sits in one place.
Take her to the vet, as soon as you can. Cats generally do not show that they're not feeling well unless they're really not feeling well. I'd consider this situation urgent unless and until your vet tells you differently, which he can only do after an examination.