Tuxedo's not responding to treatment anymore

ldg

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Some of you may remember, Tuxedo was diagnosed with an autoimmune disease a little over a year ago. It causes his system to attack his red blood cells as if they were a virus. He went on immune suppression drugs (first leukeran, then 5mg of prednisone twice a day), and for a while there had to have daily shots of human drugs that caused his bone marrow to produce red and white blood cells again (epogen and nupogen). The Epogen and Nupogen worked, and kicked his bone marrow back into production mode. We kept him on immune suppression until sometime back in February, when his red blood cell count normalized and stabilized (40 is average normal, below 24 is anemic). Doc had us start weaning him off the prednisone. Everything was going fine. But once we switched to once every other day, his red blood cell count fell off the map again (to 17 from 33). We immediately put him back on prednisone twice a day - and it didn't change. So we started him on Epogen again. Climbed back up to 23. (He's been at the vet every other day for several weeks now). Then it climbed to 27, and we were all so relieved. The next visit - it had fallen to 17. No known reason. Just that cats, sometimes, stop responding to epogen.

That was last friday. Monday it was still 17. Today it was 16. We've already consulted all the experts, and our vet has spent the last week doing more research. Just in case they missed testing him for a blood-borne disease, they've put him on doxycycline (sp?). Not helping. He's on specially made iron supplements. All the vet could come up with is switching him from prednisone to an anabolic steroid. It's being compounded for him now, and we can pick it up tomorrow morning.

Tuxie's nose, mouth and foot pads are so white. And he doesn't do much except sleep. He does come to visit us in the kitchen or the bedroom from time to time, and all we can do is try to keep our spirits up for his sake. He's gone from 10.5 pounds to 9 pounds - and is losing about an ounce a day now. The problem is not that he's not eating - he is. It's that his system isn't metabolizing it the way it should. If the anabolic steroids don't work, if things keep moving at the pace they have been, Tuxie's only got several weeks left to live.
 

kiwideus

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Oh no! Tuxie is in my thoughts and I hope that he makes a turnaround soon! But if that is not the case, then I hope he is at peace!


 

valanhb

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Oh Laurie, I'm so sorry to hear about this!! You and Gary and Tuxie are in my thoughts and close to my heart.

Have you tried and/or talked to your vet about Transfer Factor? Tammie's (MsJazz2U) Jake also has/had an autoimmune disorder that manifested itself in infected sores on his skin. I know you probably don't have time to read the whole thing, but skim thought her posts here: Jake, Very Sick It literally saved his life. Absolute miracle. I know Tammie can give you more information on it...but I thought it would be worth passing on in case you haven't considered it. Just seeing Jake's recovery has made me a believer!
 

rapunzel47

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No suggestions here -- just lots of vibes and prayers for Tuxie and for you.
So sorry to hear of this setback.
 

stormy

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Sending lots of good vibes to Tuxedo.
 

jennyr

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So sorry to hear of Tuxie's latest problems. I hope you find the best solution for him and for you.
 

esrgirl

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I am so sorry to hear about Tuxedo. I think it's one of the hardest things you can face, when a beloved pet becomes so sick. You two are both in my thoughts.
 
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ldg

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Thank you so much for all the thoughts, prayers and good vibes sent Tuxedo's way!!!

I will repeat once again that I LOVE our vet!!!!!!!!

He spent several nights researching the problem, and found something at the Institute of National Health. He checked back through Tuxedo's file (which is so thick it could be for a 20 year old cat already!) and noted that there was a correlation between the use of antibiotics and high red blood cell count. Apparently, there's a chance that instead of being an autoimmune disease, it could be an as yet unknown blood disease (apparently not so uncommon in cats). He said that Tuxie's currently got an elevated protein count, which would also correlate to this theory.

So.... he's now on both Doxycyline and CEFA drops. Stopping the prednisone shut down his adrenal glands, so he didn't eat over the weekend and he lost 6 more ounces. Dr. Bladek apologized for that major oversight, and corrected it with a shot of dexamethasone (a more powerful steroid in the same class as prednisone). That was Monday - BUT his red blood cell count had stabilized at 16 (remember, below 24 is anemic and around 40 is normal).

The GREAT news - he perked up a bit Monday night, and yesterday he was chowing down everything we gave him. He was back to bounding up the stairs (instead of just lying on a pillow downstairs) - followed Gary around as per usual - resumed his perch on top of the curio in the living room (tallest thing in the house). Boy were we hopeful about this numbers today, and.... his red blood cell count was up to 20, and he hadn't lost or gained any weight (Tuesday's eating offset Monday's not eating).

He's still chomping away, and the anabolic steroids should really help him bulk up quickly now that he's eating again. The antibiotics seem to be working, and we have got our fingers crossed that his red blood cell count will continue to rise.

Tuxedo - as Gary and I whisper to you many times a day - be a good "red blood cell" boy!!!!!!!!!!!!!!!!!! He is SUCH a fighter - what a cat. We love him so much!!!!!!!!!!!!!

THANK YOU THANK YOU THANK YOU!!!!!!!!!!!!!!!
 

ciera23

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Awww, lots of prayers to you and Tuxedo!!! I am so glad to see that there was a positive increase!!
 

huggles

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oh Laurie what wonderful news....

I didnt know that Tuxedo had these problems and I read this thread with my heart in my throat.... but what wonderful words to read on your last post

what a wonderful boy you are Tuxedo - keep fighting sweeetheart
 

cjandbilly

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I just found this thread, else I would've responded sooner. I am so glad to hear of the recovery he has already had, and I pray that he continues to recover!
 
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