We have 2 cats that we got from the Human Society as kittens. Zipper & Tazz are now 3 years old. Tazz is the hisser. Over a year ago she became very aggressive and started after her sister, hissing and growling. We think that catnip triggered this response. No more catnip in our house! Tazz is on a very small dose of kitty prozac as advised by our vet. (We tried to take her off the medication and she hissed over 10 times a day!) She still gets upset very easily. If she is sitting on my husband's lap and he moves just a little she will start meowing like she's getting upset and then it might continue with a hiss. She likes her sister but if they are cleaning and things don't go her way she will meow & hiss. We tell her no (loudly) but I wanted to know if there are any other suggestions. Tazz can be so sweet and nice. Maybe she's just too spoiled! She is terrified when people come over and hides under our comforter. Zipper likes to be the center of attention when we have visitors.