My beautiful and deeply loved kitty, Sasha, passed on today. And I think it was my fault. And I hate myself for killing the one true love of my life. She and I had been together for nearly 22 years. I work from home so we spent every day together and our bond was so incredibly strong. She has been in kidney insufficiency for the past 8 years but with regular sub-q fluids it was very stable. On Monday I found her straining to poo and nothing came out. I gave her an extra small dose of fluids to help things along and all her favorite foods with pumpkin so she could poop. By Thursday she still had not pooped and was getting picky about eating, even refusing some of her favorites. But she still ate other things (fresh chicken livers from the neighboring farm, fresh rotisserie chicken, fresh organic salmon) when offered. She was drinking a lot and a bit lethargic but still mostly normal walking around the house and having a bath on the deck. Thursday at 2:30pm since there still was no poop I took her to the vet. They X-rayed her and found a good sized poop/hairball in her colon. It wasn't scary big so the vet decided to give her an enema to help her pass it. The vet also ran blood work which would be back the next morning. When she got home she was very wobbly and uncomfortable. On vet directions, I gave her another small dose of sub-q fluids. She tried repeatedly to lay down in four of her favorite spots but couldn't get comfortable. Finally she did lay down under our bathroom heat lamp and napped. I checked on her periodically and even encouraged her to walk around. But she was so wobbly she just wanted to lay down. Her position was a bit unusual as the day went on - she was flat on her stomach/chest with tail straight out behind her. Around 10pm my husband checked on her and she let him brush her chin and shoulders (she likes that), then stood up, turned around and laid back down. About 45 mins later I went to check on her and found her in the living room in severe distress. She was wide open mouth panting and drooling and gasping. Her back legs were not functioning. We rushed her off to the nearest pet ER which was 45 mins away. On the ride she moved a little but kept open mouth panting and drooling and was unable to keep her head up. Got her to the ER where they made us wait 20 mins to see the vet. He finally took her in the back and said she had a small cardiac moment so they put her in kitty ICU box with heat (her temp was down to 98) and oxygen and they were going to do tests. When tests came back 30 mins later they said she had low WBC and high pancreatic readings and a small heart. Vet suspected acute pancreatitis and septicemia. They gave her several meds to bring her BP up, fluids, antibiotics, and pain killers. By 3:00am she had become unresponsive (coma) and they had to intubate to keep her breathing steady. He advised we let her go so we cried hysterically and kissed her 1000 times and let the vet gently stop her heart. And mine too. At 10am I got a call from her nomal vet, the one who gave the enema, and told him what happened. He confirmed that the first blood work from 2:30pm showed no sign of pancreatitis or septicemia. So all I can think is the enema caused the whole thing by affecting the osmotic pressure and dropping her BP and sending her whole body into failure and killed her. And if I had just not taken her to the vet she would still be alive. She would have eventually pooped it out and would have been fine. And now it's all my fault that my sweet baby was just fine and I put her through painful torturous hell for no reason and killed her. She didn't want to go to the vet and didn't want the enema but I made her go. She'd be sitting on my lap purring now if I had not let the vet give her an enema. Now she's dead. How on earth do I live with myself having killed the one companion I loved more than my own life? How do I live with the guilt?