Sugie went and pooped and peed inappropriately in the house again on the weekend. There was nothing new in the house and no changes at all to her or our routine! John was ready to put her down as he has reached the end of his rope. I talked him out of it (made for a miserable Valentine's day) and convinced him to try the new anti-anxiety pill the vet suggested - Clomapine (sp?). She started it on Sunday and since then she has barely had anything to eat or drink. She hasn't used her box at all since Saturday. Her tummy seems hard. I have a call in to the vet. I don't want to put her down, but we are running out of options to control her. We have tried Feliway, Bach's Rescue Remedy, different meds, behaviourist, box retraining and while it may work for a short time, it never lasts. She used to go months without incidents, now it is ever 2 weeks! I have even tried to find her a new home with no other pets and no children. No one wants her because of her issues. I just don't know what to do anymore! Come on vet - call me back!