best way to administer DMG

wannahelp

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I just purchased DMG for cat. I'm hoping it will help her chronic problems.  However, she does not let anyone near her mouth.

Can I put it on her food? How many mL are in each drop?
 

stephenq

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I just purchased DMG for cat. I'm hoping it will help her chronic problems.  However, she does not let anyone near her mouth.

Can I put it on her food? How many mL are in each drop?
Can i ask why you want to administer DMG (Dimethylglycine)?

From this website: http://www.vcahospitals.com/main/pe...article/animal-health/dimethylglycine-dmg/263

"Dimethylglycine is a highly unusual supplement, in that it is extremely popular despite the fact that all of its touted effects have largely been refuted by clinical and laboratory testing. It is most widely used as a performance enhancer by athletes, and in dogs and horses that are bred for racing purposes. Specifically, DMG is thought to be able to reduce lactic acid build up that might otherwise contribute to muscle fatigue. There is no immediately obvious reason why DMG should be able to achieve this, given its role in the body as a metabolite of betaine and a source of glycine. Reports of an ability of DMG to enhance athletic performance first appeared in the popular literature in the 1980's. Controlled studies involving treadmill horses, male athletes, and patients prone to lactic acid build up due to a cytochrome oxidase deficiency fail to support these earlier claims. Other common uses of DMG which have been refuted by clinical research include the treatment of autism and idiopathic epilepsy."
 
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wannahelp

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A poster on this site suggested it. After researching it further, it seems that a lot of cats with compromised immune systems have improved while on it.
 

stephenq

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I don't think there is good evidence for that claim.  All the well controlled studies say completely the opposite, in fact they say there isn't a single well done study that indicates otherwise.  If you're giving your sick cat something that doesn't actually work, not only are you loosing time and money, you're stressing your cat out for no reason and that could actually make your cat sicker.  On top of that he could be getting treatments that actually work but he isn't

I've looked at a lot of website that talk about DMG in cats and humans and it seems that all the webites that are "pro-dmg" are either trying to sell it to you or are just very snake oil oriented.  Many people complain about "Big Pharma", but frankly "fake pharma" is even worse.

Can we know why you are trying to boost your cat's immune system?

In the meantime  I would urge you to read the article above in my first reply, and the links below.

The NIH study at http://www.ncbi.nlm.nih.gov/pubmed/1381880, one of the most respected health organizations in the world concluded in its study that "Results of this study of DMG in healthy cats failed to demonstrate enhancement of either specific or nonspecific immunity."  Done over many weeks in many dosages the NIH tried to boost the immune systems of healthy cats and tested them against a control group and found no difference.

Wikipedia talks about its use in humans here: https://en.wikipedia.org/wiki/Dimethylglycine
 

stephenq

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Since i've had my cat, she hs had chronic problems, which were originally labeled URIs but now seem to be more like sinus problems. She is often very congested and occasionally makes a hacking sound, which I'm told, is essentially from post nasal drip. She is congested more often than not and medication for allergies has caused her to vomit. Other people with similar problems, claim to have seen positive results from DMG. More
OK, are you trying to give a full capsule or my another method?  There may be some ways of disguising the capsule or its contents, so if you describe the way in which it comes maybe we can come up with something.
 
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wannahelp

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It's liquid with a dropper.
 

stephenq

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It's liquid with a dropper.
Liquid is a problem.  Powder could be added to gelatin capsules, pills disguised inside pill pockets.  About the best you can do with liquid is mix it with some gravy or chicken broth.  Unless you can get powder or pills, and depending on how much your cat fights you, you're going to have to decide how worth it is to you and your cat to stress her out daily over this, particularly when despite anecdotal stories of its usefulness, there has never been an actual scientific quality study that supports it.

Its interesting when one looks at double blind studies - that's when neither doctor nor patient knows who's getting the drug or the placebo, these were started when it was discovered that even the most well meaning study, with well intentioned doctors shifts the results in favor of the drug when the scientists know who's getting the drug or when the patients know if they're getting the drug.  Both groups unintentionally report and "see" better success just by knowing they are getting the drug.

While we should be wary of Big Pharma, we should be running away from the quacks who are giving us wonderful stories and then telling us to buy their product.  I had a friend who had a cat who was dying from FIP, a terrible cat disease.  She said this new vet had a cure, but that no one else had heard of it yet.  I told her, believe me, if a doctor had a cure for FIP, the whole world would know it.

And as an example of how hard it is to tell if a drug actually works better than a placebo, today Lily announced it was cancelling a study for a new heart drug in its FINAL stages after years studying 12,000 people in 37 countries because they finally figured out it wasn't working.
http://www.nytimes.com/2015/10/13/b...id=nytcore-iphone-share&smprod=nytcore-iphone
 
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