Bad Kitten Reaction to Shots/Flea Pill

On Tuesday, we took our 14 week old kitten in for her second round of shots. At the appointment the vet also prescribed Comfortis for fleas. After her shots she seemed to be really lethargic and wasn't feeling well, but after sleeping most of the day after the shots she started playing again.

We gave the flea medication yesterday at 5:30 pm since she seemed like she was feeling better, which I am thinking now was probably a mistake. Looking at the tablet, the vet gave us a higher does of the medication than she should have had. From what I have read about the drug, overdosing on it just results in higher prevalence of the side effects of the drug without any extreme reactions. A few hours after being given the flea medication, she threw up some of the wet food (but not all of) that we gave it with and then quickly appeared to be feeling better and was playing some, eating, drinking, and peeing.

Last night, she wasn't feeling good again and spent most of the night snuggled up against me. When I picked her up in the morning, it seemed like she was feeling sore, because she cried if she was picked up around her middle. She also swatted my other cat when he licked her sides. She wasn't running around but walked fine and mostly just slept during the two hours before I went to work. She also ate a lot of food scarfing it down quickly as if she was starving.

I know lethargy and vomiting are side effects of this pill, but she seems so sad and upset. She is also on liquid antibiotics for the URI that she had previously. Is she just feeling bad because of all of the drugs in her system? Has anyone else had cats or kittens react this way to their shots or the flea pills? How long did the side effects continue?

Any help would be greatly appreciated.

I've read a lot about shots online and I know the lethargy is normal for that as well. When should I really be worried? Soreness appears to be normal with a shot, but is it normal for that to have appeared today rather than yesterday? She got her shots at 6pm on Tuesday so it hasn't yet been 48hrs out of shots.

I just really need some reassurance.

Did you call your Vet about this?  That's the first thing I would do (although now it's after hours, naturally)

With my cats, they are usually lethargic for about 24 hours after getting their shots, then they're AOK.  They don't get flea meds though because we don't have fleas where we are. 

I don't know why she would be sore, because surely she didn't get any shots in her midsection?????  Usually they give shots either in the legs or tail, just in case there is the "worse case" scenario. 

She had shots in her back flank, so I'm not sure about the soreness, though maybe this would be nausea related? Then again she's eating so she's probably not nauseous. I have also read the shots can cause all over muscle soreness so this might be it. I will check on her when I get home from work. If she is still not feeling good I will call a vet. My vet is a farm vet, so he doesn't have any real "business hours". I also have an emergency vet line that I can call and check with. Hopefully, she'll be okay when I get home.

I'll have to check her litter box for vomit. She threw up in her litter box last time and buried it neat as can be.

Wow!  Isn't she a good girl!  Wish mine would be so accommodating.  My kidney cat throws up pretty regularly, and when she does, she spins in a circle, getting it all over her feet and then, naturally, runs away when I come over to clean everything (including her) up.    Luckily it's usually just an almost clear froth, but still.....

Hope your little one will be in tip top shape wten you get home

I got home and she was mewing to  get out of her crate. She is playing fetch with crinkle balls and running around as normal. I guess she just needed to sleep it off.

Great news