I use it. Advantage 2 stopped working at 2 weeks, Frontline had ZERO effect for him. Drawbacks? More expensive (bring in vet copy of Drs Foster and Smith catalog snd kindly they will match the price), cat has become almost violently opposed to the application. But I believe in it. Kills many internal parasites too.
I've used Revolution on and off for years (I think at least going on 5 or 6) and it still works great. I use it on both cats and dogs in our household. It is sadly more expensive so during the winter months they sometimes have to go without it (I use something cheaper during this to still cover the heart and other parasites).