Cats hate eachother

guy i need some help, my cats cant get along!

so 5 months ago we got a cat named opal, she is try deaf and clueless. we did the whole introduction thing and misty was sort of ok with her sent, a little hissing here and there but not to bad. heck even when they saw face to face a bit between the door she was ok. after a few more days we let opal stay out for a night.... it did not work out well. misty has been hiding from her ever seince. every time opal sees misty she wiggles her little butt and starts chasing her. opal is not agressive she onky wants to play but misty is scared to death. opal is deaf so he can not hear misty's hissing and she has no idea ears back means i am scared dont play with me. opal meows for misty all night and misty just hides under the bed. misty cant even walk around her own house if she sees misty a yard a wayfrom her. what can i do? we have tried giving them both calming collars but it only helped for the first day. should we give misty some drugs? (yes its that bad). this is stressing out the whole family and we can not give up opal.

It sounds to me as though you didn't fully complete the introduction phase.  It can be a lengthy process and is not done in the matter of a few days.  First off, I would redo introductions.  Yes, it will be a pain and it may take awhile to undo the damage.  Misty is terrified.  You will need to show her that life with Opal can be ok.  I will post some links and a video on the process.  I would start completely at the beginning and not move to the next step until all growling, hissing, and running away is complete.  Find ways to allow Misty to be safe.  You can put Opal away for a time period and lure Misty out with yummy treats or even plain cooked chicken.  You needs to be reassured. 

I also would invest in a few feliway plugs ins.  This will help to calm the household a bit.  Place one in the room wherever Misty hides and then one in the main area of the house.  I have had really good luck with Composure liquid Max.  It is a calming product that can be mixed into the wet food.  I tried the treats and they didn't work very well, but the liquid 2x a day worked well.  I gave it to both of my cats at first.  I gave 1/2 t. each morning and 1/4 t. each night. 

When you are not home, I would be sure that Misty is always safe.  Either close the door to her room or put Opal away.  Since Misty needs reassurance you may want to be sure you has access to vertical space.  A place where she can jump out of the way to safety.  This can be a cat tree or even shelving on the wall.  You can go to Jackson Galaxy's site and take a look at this "Catification" ideas. 

Do you play with the cats individually?  Play really helps a stressed timid cat.  The da bird toy is awesome, but start slow with Misty.  She really needs to get her confidence back. 

Have you looked into information about how to live with a deaf cat?  There may be ideas that would help.

Here are some links:

http://www.thecatsite.com/a/introducing-cats-to-cats

http://www.catbehaviorassociates.com/a-simple-little-trick-to-use-during-new-cat-introductions/

http://jacksongalaxy.com/2010/10/01/cat-to-cat-introductions/

I had a very similar situation to this. Eerily similar, actually.

Six years ago, I adopted a white, deaf cat from a shelter. My resident cat, Shady, did NOT take to the new cat at all. Ghost, the deaf cat, would run at Shady and attack him. He could not hear Shady's hissing and growling. Shady would hide every single time he would even see Ghost.

Six years later and unfortunately Shady passed away... but after about six months they became friends. Well, they tolerated each other.

I will let you in on what I did and maybe it will help you.

First of all, the Feliway plug ins did not work. You could try them, they work for some people, but they did NOT work in this case. I have bi-fold doors between the two sections of my house and I put one cat on one side and one cat on the other side. I would open the doors once a day to feed the cats together. At first, I put Ghost, the deaf cat, in the pet carrier and gave him food in there and I let Shady, the resident cat, eat out in the open. Over the course of several months, they gradually started to like one another.

My husband and I would alter what side of the house we would be on. I would play video games with Ghost one night and then I would watch TV on the other side with Shady on another night. Every once in a while, I would try to introduce them again and it would not go well and I would separate them again.

I'll be honest, it got so frustrating that I almost had to re home Ghost. :/

Six months after I got Ghost, I ended up getting fed up with the doors being closed. I opened them just to see what would happen. Ghost ran at Shady, but then Shady jumped up on the chair and got away from him. I let them together for that entire day and there was not an incident at all, so I just kept them together. I don't know what magically changed, maybe enough time passed, maybe Ghost got old enough that he didn't feel the need to terrorize Shady. It did eventually get better, though.

I can empathize with what you're going through, though. It's really hard with a deaf cat. It can be done, though, you might just have to separate them and start over again. :/