Freckles has advanced Kidney Disease and blood levels off the chart at stage 4. I have tried flushing 2 times and he came back a bit better, that was a month ago. Levels went down but now are back up. One month later he is now not eating very much but drinking water. I tried IV fluids for the first time, at the vets, yesterday. Vet says with blood levels so high that he recommends not to do more IV fluids and to think of the well being of my cat and consider euthanasia should he continue not to eat. He lost 1.24 lbs in one month. I am so hesitant to consider the vets advise dueto the fact Freckles does not seem to be at the end of his battle. I have had cats losing their battle with Kidney Disease, and Freckles just does not seem to be there. He does groom himself, wants loving all the time, walks about the house and wants to go outside every so often for a few minutes. I am trying baby food, chicken broth, wet food, and now will try tuna juice as recommended by someone on this site. When is it a good time to give up and consider the cat's well being? What are the signs that the cat is truly suffering? Do I keep on trying more with Freckles? If I could only get him to eat!