A minor success!
After cleaning up this morning, and administering the Amytrip and Probiotic, went to work. Mrs. was in the house for a couple hours before I picked her up and we were out again for a bit.
When we got home she was just sort of moving through the house, ignoring any sweet talk we were sending her way. She tolerated petting. We put some fresh food out, and she ate. Then she disappeared.
As quietly as I could, I made my way down the basement stairs. As I got to the bottom, she came slinking out of the litter box room, looking guilty. I tried to talk gently to her and reach to pet, but she apparently thought I was going to make a grab, and she crouched even lower to the floor before breaking up the stairs, but she stopped halfway and glared back at me.
When I went in the room, I didn't see any immediate concern, so I wasn't sure what she had been up to. BUT, I quickly discovered what was either a marking or a standing urination punctuated by a blob of diarrhea on the inside back wall of the open-air tub. NOTHING on the floor! Never thought I'd be that excited about cleaning a litter box, but this is very hopeful. We praised her and gave her a few small treats to celebrate, but I think it just confused her.
I'm now wondering if this has been a progressively worsening bowel problem since July, and if the Probiotic gets that straightened out if it will correct the urination issue. Her last stool sample (months ago) that Vet #1 checked didn't indicate anything, but I also don't think they looked for anything besides obvious parasites, etc.
Sassy is playing it really aloof and reserved. Last night, after medication, I tried to offer one of her favorite treats, Petromalt. I had it on my finger, touched it to her lips, and she turned her head, ignoring me, seeming really angry. You have to understand that she really likes Petromalt. Hoping the medicine levels off a bit.
Not betting the house on it yet, but this is hopefully a good sign.