recovering from pancreatitis

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chrisandwillis

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A little background on Willis, the brown and white tabby protagonist:

Willis was about 10 years old and a little over 8 lbs on a long lanky frame when I got him.  He had a history of vomiting.  He needed frequent small meals throughout the day.   He was eating kibble at the time, and he was transitioned to a grain-free canned diet.    He would vomit if given more than about 1/4 of a 5.5 oz can, or 1.4 oz, at a time.  So he ate 4-8 small meals a day, depending on the food.  He would also vomit yellow/foamy liquid when his stomach was empty.  We went through a period of diarrhea and trial and error before finding canned foods that worked for him.  He had one emergency vet visit for vomiting + diarrhea, when he was tentatively diagnosed irritable bowel, but since his diarrhea cleared up and he reverted to "only" periodic vomiting, once every two weeks or so, I didn't pursue the diagnosis.  Every so often he would lose interest in his favorite food, and I'd have to find another food he liked.  For about a year, he ate Soulistic brand from Petco, and vomited very seldom on it, so despite its relatively high carbohydrate content for canned, I thought we were doing OK.  At his chubbiest, he weighed in at 10 lbs 8 oz; I think a healthy weight for him is about 9lb to 9 1/2 lb.

Now, he's about 14 years old, and he went off his Soulistic after trying to eat breakfast two mornings in a row and vomiting both times.  I took him to the vet, and after an ultrasound he was found to have an inflamed bile duct and pancreatitis.   He had a feeding tube put in, and he has been eating Hill's a/d through his tube.  He's become jaundiced and has lost additional weight.  He's 8lb 8oz now.  He spends most of his time resting, and I feed him as much as I can in the hopes that we can turn this around.

What he's getting:

120cc's of Hill's a/d, in 30cc doses 4x/daily

15 mL of Nutri-Cal supplement once daily

0.2 mL prednisone 2x/daily

2 mL reglan 2-3x/daily

1 mL amoxicillin 2x/daily

0.05 mL buprenex 2-3x/daily

100 mL Lactated Ringer's solution subcutaneous 2x/weekly

He also gets weekly B12 injections from the vet.

I think he will be able to handle a fifth 30cc meal without vomiting, which should in theory get us to 180 calories per day.  His stools are formed but soft and are the color of the a/d, and I'm concerned that he is not metabolizing well.   I mentioned digestive enzymes and the staff laughed at me but gave me some Proviable-DC.  What else can I do to help him?
 

scarlett 001

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I am in a similar situation to you. My kitty was diagnosed just two days after Christmas with inflammation/distenson of bile duct and maybe mild pancreatitis. I have to get a copy of ultrasound report to understand which of her issues is causing her more problems, but I think in her case the bile duct is more of the issue. My regular vet has been on holidays so I have not talked to her yet, although there is another vet at the clinic who is great and some of the vets at emergency clinics I have been to in the past few weeks have been helpful.

She did not get jaundice thank goodness and is eating enough to not need a feeding tube. So far we have her on prednisolone once daily and subq fluids 2x a day (smaller amounts only). She also as on antibiotics. I will start vitamin b12 injections soon and also have buprenex on hand if need be. Sounds pretty similar to what you are doing.

She is not her old self, but has some days that are pretty good and some are a bit more lethargic looking. Perhaps we can keep in touch as we both work through this as our kitty's issues are quite similar.
 
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goholistic

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I'm so sorry you and Willis are going through this.  
  I can certainly relate and your story of Willis' vomiting and fussiness with foods sounds all too familiar.

Did the vet have the spec fPL test sent out to Texas A&M? This is the blood test to test specifically for pancreatitis. This is often helpful to have along with the ultrasound. Sometimes IBD goes hand-in-hand with pancreatitis...and just overall inflammation that travels. Sebastian has confirmed pancreatitis, and suspected IBD as the cause or a concurrent condition.

I have experience with feline pancreatitis, but not with tube feeding. Sebastian was lucky in that he/we bypassed hepatic lipidosis (fatty liver). A feeding tube was definitely considered if he didn't start eating on his own, but I pursued syringe-feeding with determination. So Willis became jaundiced after 2 days of not eating?

You may want to ask your vet about using Cerenia in place of the Reglan. My vet used to use Reglan for vomiting/nausea, but now prefers Cerenia. But since Cerenia depletes Substance P of the central nervous system, they have to have a break from it so that Substance P can replenish itself. Sebastian is still on a low dose of Cerenia Monday through Friday (5 days on, 2 days off).

Prednisone doesn't metabolize by the liver as easily as prednisolone. But prednisolone is difficult to get nowadays. Others have used different steroids, like Dexamethasone or Budesonide.

It's my understanding that amoxicillin can cause an upset stomach. The antibiotic of choice for pancreatitis kitties is usually Metronidazole because it possesses anti-inflammatory properties.

Fluids are important, so I'm glad to see those being done. I still give Sebastian fluids every two days, even when he is doing well. I always check first to make sure the last session is fully absorbed.

The only thing I don't see on your list that my vet advised to give Sebastian is Famotidine (Pepcid AC, original formula). He gets 1/4 tablet twice daily (AM and PM). Excess acid can cause nausea and so the Famotidine helps with this.

In my opinion and my vet's opinion, digestive enzymes are controversial for pancreatitis, unless exocrine pancreatic inefficiency (EPI) is a diagnosis. Many people recommend them, but I wasn't (and still not) willing to take the risk. If the pancreas is producing enzymes just fine, I figure don't try to fix what's not broke. It's the inflammation that is the problem...again, IMO.

I do give Sebastian probiotics at night 2-3 hours after the Metronidazole (which he is also still on at a low dose). This helps replenish his healthy gut flora, which is being destroyed by the antibiotic.

Sorry for the long response. 
 
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chrisandwillis

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Scarlett, I'm sorry you're in the bile/pancreatitis club now too.  Some holiday, huh.  It sounds like your kitty is doing fairly well all things considered.  Definitely keep updating on how things are going with her.  I hope she's healthy again soon.

GoHolistic, thank you for the long response.  :)  I'm new to pancreatitis and I can use all the information I can get.  How long have you and Sebastian been doing this? 

We did get the spec fPL/IDEXX test and that returned normal results (that's what the vet told me; I don't have a copy myself.  I should ask for one).  But when we had the ultrasound a few days later, that showed the bile duct inflammation and affected pancreas--though liver and kidneys still looked good at that time. 

Willis actually took about two weeks of anorexia/inadequate calories to become jaundiced.  I didn't lay out the time line very well in my original post.  He got his feeding tube before Christmas and had a yellow tinge by January 1.  I'm trying to get enough calories to him but he will not tolerate more than 32cc per meal and it's taken us a long time to get him up to 32cc 4x/day without vomiting.  It took tiny steps of a few more cc's each day.  I hope he'll accept 5 feedings/day so he's getting all his calories from proper food and not the Nutri-Cal.

He sounds bad, and he is resting a lot, but he still has life in him.  He isn't hiding.  He's grooming himself and using the litter box and trolling for breakfast and jumping up on the bed in the mornings, even though he won't eat more than a few mouthfuls on his own yet.  He still uses his scratcher and jumps up in my lap from time to time.   As long as he's willing and not obviously suffering, I am going to try to get him back to health.

I haven't asked the vet about different steroids; I live in a small town.  Maybe Prednisolone isn't available.  I would hope she'd have prescribed it if it's preferable to Prednisone.  I can't remember why we're doing amoxicillin only now, but he was on Metronidazole for a while too. 

Probiotics, check.  Digestive enzymes, back on the shelf for now.

Pepcid, that's right, I heard that was good.  I'm a little afraid to give him anything via mouth.  He's still a fighter if you try to force anything in there.  I don't suppose I could give that via the tube somehow?
 

white shadow

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Hi ChrisandWillis !

I have not dealt with pancreatitis in any cat.

I do have a couple of references for you.....

- A reliable website, written in plain language, by someone well-known in the feline community, which includes references for everything discussed: http://www.harpsie.com/pancreatitis.htm

- A specialized online group of people who are managing their own cats' pancreatitis - founded in 2007, the group has had almost 1000 members. These groups have a wealth of collective experience to offer newbies - and they're known to be knowledgeable about the latest treatment information. Just press the purple + JOIN GROUP button here: http://groups.yahoo.com/neo/groups/...=1&t=search&ch=web&pub=groups&sec=group&slk=2
Pepcid, that's right, I heard that was good.  I'm a little afraid to give him anything via mouth.  He's still a fighter if you try to force anything in there.  I don't suppose I could give that via the tube somehow? 
Sure.......use the oral suspension:
 
Famotidine Oral Suspension

If your cat is hard to pill, famotidine is also available as an injectible or an oral suspension (liquid).

Thriving Pets sells a 10mg/ml oral suspension (liquid) version of famotidine in a 30ml size, so if you want to give the usual famotidine dose of 2.5mg, you would give 0.25ml. This product has a short shelf life, so you should not order more than 14 days worth at a time (including delivery).  Like the pills, this form of famotidine is also very bitter, so if you don't want to give your cat bitter oral medications, consider using injectible famotidine instead. If you enter the word "tanya" (without the ") in the promotional code box, you will receive a 10% discount on orders over US$55. Shipping is free for orders over US$55 after the discount.

Famotidine Injectible

There are two types of famotidine injectible. There is a 10mg/ml strength without preservative, which is available in 2ml vials. Because it contains no preservatives, this has a short shelf life (it is intended for single use in humans). There is also  a 10mg/ml strength available in a 20ml size vial. This contains a preservative and can be re-used, though it should be kept in the fridge.

You can use the injectible either by injecting it directly into your cat, or if your cat is on sub-Qs, by adding it to the injection port of your IV line. It is safe to take it out about 30 minutes before using it so it can warm up a little before use.

Thriving Pets sells the 10mg/ml injectible form of famotidine in a 20ml size, so if you want to give the usual famotidine dose of 2.5mg, you would give 0.25ml. If you enter the word "tanya" (without the ") in the promotional code box, you will receive a 10% discount on orders over US$55. Shipping is free for orders over US$55 after the discount.

http://www.felinecrf.org/nausea_vomiting_stomach_acid.htm#famotidine

(btw, the author of this site is the woman who wrote the Harpsie site above)
I have a feeling that he would also benefit from Denamarin.....it is well known to help liver recovery - that, you would have to pill, though. Talk to your Vet about it: http://www.nutramaxlabs.com/cat/cat-liver-health/denamarin-for-cats (and/or ask the people in that group....actually, I'd ask them first)
 

goholistic

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GoHolistic, thank you for the long response.  :)  I'm new to pancreatitis and I can use all the information I can get.  How long have you and Sebastian been doing this?
Since July 2013. His pancreatitis wavers. He's had one severe attack, which was the first and required hospitalization for a few days and syringe feeding. He had two moderate attacks - one in September 2013 and the other in October 2013. These three attacks were all accompanied by his major symptom - continuous, severe vomiting - along with lethargy, anorexia and pain. There have been occasions in which he walks away from his food and sleeps all curled up which are probably mild attacks and he's in discomfort. When he's eating well, grooming and playing, I know we've got things under control. But it all comes on so quick...sometimes within hours. Sebastian has his own thread, but it's REALLY long: http://www.thecatsite.com/t/264363/sebastian-is-back-at-the-vet-suspected-pancreatitis-again

This is my favorite document from Idexx on how to treat pancreatitis:

http://www.idexx.com/pubwebresource...pec-fpl-treatment-for-feline-pancreatitis.pdf

That's very interesting that the spec fPL results came back negative. This test measures elevated pancreatic lipase characteristic of pancreatitis. Is it possible that Willis just has inflammation in the upper GI tract? 


It sounds like you're doing a great job nursing him back to health. Grooming is a great sign and the fact that he'll eat anything on his own is a wonderful sign, even if it is only a little.

Hugs for you  
  and lots of vibes for Willis! 
 

cprcheetah

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I have a kitty who was diagnosed with Chronic Pancreatitis.  I have her on Digestive/Pancreatic Enzymes and I believe they have helped a lot.  The protocol for treatment your kitty is on sounds pretty standard.  I have been doing a lot of reading and have read that EFA's can help with inflammation, so I am giving my DeeJay Krill Oil once a day.  She is also on antibiotics and steroids and appetitie stimulants as needed. 
 
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chrisandwillis

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Inflammatory bowel, not irritable, in my OP. You probably all knew what I meant.

I am so grateful for your input and vibes, prayers, good wishes. I know there are kitties who have recovered from serious flare-ups or acute pancreatitis, but my brave Willis did not make it. He vomited his breakfast on January 5 and dislodged his feeding tube. When we got to the emergency vet they said he was anemic, lowered heart rate, and his liver was beginning to fail. The vets helped him pass peacefully at 11:15.


Sitting in the sun when ever he wants, with no barfing and no tummy ache ever again. Goodbye love.
 
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