I just have to say that hissy's method works *really* well. When Jack was sick I had to do the same thing to him. At first I figured he'd be less scared if he wasn't wrapped up and boy did I pay for that - he bit me really hard and scratched my arms up. After using the towel for a while he would run from me. Jack had a pretty severe URI and couldn't breathe through his nose really well, so I couldn't shoot all the medicine in his mouth at once. What I did is, while holding him, I'd kind of kiss him on the top of his head and pet it as best I could with the hand not holding the syringe. I spoke calmly to him during "Medicine Time" and he stopped squirming so much. I imagine this might be impossible with some cats, but for him it worked really well in addition to hissy's technique. Good luck!