Perscribing Metronidazole for treatment of IBD. Is this counter intuitive?

carolina

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Carolina, Cerenia is an anti-emetic. I'm not sure why you're thinking infection?
Brain-fart - I know - and a good one at that!

For some reason I thought Convenia :doh3:

I edited my post, but we crossed.....
 
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betsygee

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Yes, vomiting can be a side effect. It can also cause decreased appetite, depression, etc.

We had a strange experience with metronidazole. Our IBD cat's main problem was vomiting, so this med was tried first before steroids.

The vomiting stopped practically immediately, but he lost his appetite and became depressed and lethargic. By the end of the third week these side effects were so bad our vet agreed it would be best to stop the med. (We were supposed to try it for a month.)

The very next day after he was no longer getting metronidazole he started vomiting again and the vomiting was as bad as before. As if he had never had any medication for all that time. It was truly mind-boggling.

(Tablets hidden inside of empty gel caps work very well, the cat never tastes the medication.)

I can only say, if you decide to try metronidazole, keep a close eye on your baby and watch like a hawk for possible side effects such as decreased appetite, depression, etc. 
I had no idea vomiting was a side effect of this med!  One of the cats we inherited from our deceased friend is on metronidazole--indefinitely, I guess, in liquid form, twice a day.  She was taking it fine for about a month and then she started sort of dribbling it out, not swallowing all of it, and went through a vomiting stage.  She's still not getting it all down but seems to be eating better.  I think she's depressed, too.  I thought it was because she lost her "mom" (owner) of 10 years and the trauma of being relocated to our home.  Of course those things may have affected her, too, but I didn't know depression could be a side effect of this med.  Poor girl.  I've never had to give a cat meds regularly before--sounds like I need to be doing some research!  Thanks to all for the info.
 

violet

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Complete list of side effects of metronidazole

http://www.vetinfo.com/side-effects-metronidazole.html

Side Effects of Metronidazole

  • Neurological disorders
  • Lethargy
  • Loss of appetite (anorexia)
  • Nausea
  • Vomiting
  • Diarrhea
  • Drooling
  • Dry mouth (licking or pawing at the mouth)
  • Drop in white blood cell count (neutropenia)
  • Liver failure (hepatoxicity)
  • Bloody urine (hematuria)
  • Toxicity in Metronidazole
  •  
Toxicity in metronidazole is rare and only occurs with very high doses or prolonged use. The effects of toxicity are usually seen in impaired functioning of the brain and difficulty in maintaining the body's balance.

Look Out for:
  • Disorientation or staggering
  • Holding the head at a tilt
  • Tremors
  • Involuntary eye movements
  • Seizures
  • Rigidity
  • Drop in heart beat (Bradycardia)
 

carolina

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It is important to put this BEFORE putting the side effects - from the same page:

Generally this drug is safe for cats and has proved effective. As with any powerful drug, some cats may show side effects.

Read more: The Side Effects of Metronidazole for Cats - VetInfo http://www.vetinfo.com/side-effects-metronidazole.html
I am NOT pro-drugs in ANY way, shape or form. However, Metronidazol is an useful drug, and many, many cats, use it without ill effects. Every drug has potential side-effects - again, potential - it doesn't mean that the cat will for sure have the side effect.

A potential side effect of prednisolone is diabetes - it does NOT mean that every cat will develop diabetes. Just sayin' :dk:
 
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betsygee

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Complete list of side effects of metronidazole

http://www.vetinfo.com/side-effects-metronidazole.html

Side Effects of Metronidazole

  • Neurological disorders
  • Lethargy
  • Loss of appetite (anorexia)
  • Nausea
  • Vomiting
  • Diarrhea
  • Drooling
  • Dry mouth (licking or pawing at the mouth)
  • Drop in white blood cell count (neutropenia)
  • Liver failure (hepatoxicity)
  • Bloody urine (hematuria)
  • Toxicity in Metronidazole
  •  
Toxicity in metronidazole is rare and only occurs with very high doses or prolonged use. The effects of toxicity are usually seen in impaired functioning of the brain and difficulty in maintaining the body's balance.

Look Out for:
  • Disorientation or staggering
  • Holding the head at a tilt
  • Tremors
  • Involuntary eye movements
  • Seizures
  • Rigidity
  • Drop in heart beat (Bradycardia)
Thank you for the information, Violet!  I think I should talk to the vet about Molly's symptoms/possible side effects.
 

violet

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Originally posted by Carolina

It is important to put this BEFORE putting the side effects - from the same page:

Generally this drug is safe for cats and has proved effective. As with any powerful drug, some cats may show side effects
.

That's why I posted the link to the web site

http://www.vetinfo.com/side-effects-metronidazole.html

(Post #23)

Everything people need to know is there. They just need to read it. Not that it will change the facts about the side effects in any way.  For this thread, because I thought it was very necessary, I wanted to post the list of side effects people could check quickly for information.  

By the way, I have the same list of side effects and a ton of extra info in a drug book for cats and dogs that was published years ago. Couldn't post from there because, naturally, there is no URL. This info on Vetinfo is a great, comprehensive list. The best.  And I feel people really need to know about the side effects if one of their babies is prescribed this drug. 

"Some cats may show side effects". Can't help wondering why anyone would want to minimize how many cats suffer side effects from this med.
 
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carolina

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"Some cats may show side effects". Can't help wondering why anyone would want to minimize how many cats suffer side effects from this med.
Can't help wondering either about instigating what IMHO could be sometimes unreasonable aounts of fear in helpful drugs because of potential side effects :dk:

Yes - EVERY DRUG has potential side effects - ALL of them. I am yet to see one that doesn't.

Metronidazole happens to be a helpful drug, and IMHO the side effects need to be posted, and also it has to be said that side effects while can occur, it is generally a safe and effective drug.

There are not many things out there that help IBD kitties.

I am ALL for no drugs and "treating" with a raw diet. Already said that.

Aside from that, the drugs that are most helpful and widely available are metro and prednisolone. BOTH have potential side effects. Both are helpful.

Both need vet guidance.
 
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carolina

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To the OP - talk to your vet about the medications your kitty is taking. He is the best person to guide you.
Also about Metro - it is a good drug, but it doesn't make sense giving it indefinitely, IMHO..... Something is causing that inflammation - you want to go to the source. My cat was also on it for a long while, and every time he would go off, he would flare - diet solved his problem :nod:

Like I said before, pills/gel caps work better.

Did you get a shot of Cerenia? Did you get pills too?

How is the kitty?

How much is your kitty eating a day? How much does it weigh? How much weight did it lose lately?

What are you feeding?

:vibes::vibes::vibes::vibes::vibes::vibes::vibes::vibes::vibes::vibes::vibes::vibes::vibes::vibes::vibes::vibes::vibes::vibes:
 
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peaches08

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I'm pro-medication, but I also agree that this kitty needs food. At this point, even if it means ditching some meds.

If chicken interests him, what about plain baked chicken? Or half baked?
 

violet

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Carolina, earlier in this thread I described how sick this med made my Bernie.

People need to know about the side effects of meds so they can catch problems early and get help from their vet who can then find a different med that will be better tolerated.

I've learned a hard lesson from trying this med with Bernie. And more hard lessons when I realized one of our other cats could not tolerate any oral antibiotics, period. Thank God our vet was always there for us and found the life-saving solutions for Rosie when not having a very necessary antibiotic could have cost her life.
 

carolina

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I'm pro-medication, but I also agree that this kitty needs food. At this point, even if it means ditching some meds.

If chicken interests him, what about plain baked chicken? Or half baked?
:yeah:

Or cooked chicken breast? Plain chicken breast is great to settle kitty's tummies :nod:

I am all about food and getting to the root of the problem. To me, masking it does no good :nod:
IMHO the most urgent task at hand is to have the kitty eat and keep it down...... :nod:
 

betsygee

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Carolina, earlier in this thread I described how sick this med made my Bernie.

People need to know about the side effects of meds so they can catch problems early and get help from their vet who can then find a different med that will be better tolerated.

I've learned a hard lesson from trying this med with Bernie. And more hard lessons when I realized one of our other cats could not tolerate any oral antibiotics, period. Thank God our vet was always there for us and found the life-saving solutions for Rosie when not having a very necessary antibiotic could have cost her life.
Again, I appreciate the info, Violet.  I didn't know what was wrong with this new kitty I have.  The information you posted isn't causing me "unreasonable amounts of fear" about the med she's on, but is giving me some knowledge so I can talk to my vet about her health.  I had no idea the metronidazole might be causing the drooling, depression, etc.  
 
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jclark

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Update:

Cerena allowed us to syringe feed last night and this morning. About 1/2 can of RC hypoallergenic in total. He's of course feeling better but still won't eat on his own.

He has 1 more week of the Metro. If administered in the back of the mouth he doesn't taste much of it so drooling is kept to a minimum.

Will keep posted if anything changes.
 

peaches08

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Glad you got some food in him! Was he vomiting constantly before metronidazole, or only since he's been on it?
 

betsygee

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Update:

Cerena allowed us to syringe feed last night and this morning. About 1/2 can of RC hypoallergenic in total. He's of course feeling better but still won't eat on his own.

He has 1 more week of the Metro. If administered in the back of the mouth he doesn't taste much of it so drooling is kept to a minimum.

Will keep posted if anything changes.
Good news he got a little nourishment.  I hope he keeps letting you feed him!
 
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jclark

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Update: He has completed the round of antibiotics and just started to eat on his own (nibbling). Hoping to get him to consume about 1/2 can of food per day by the end of the week.

Assuming his eating continues it will be a matter of seeing what happens when the steroid wears off in the next 2 weeks. If he relapses then we're dealing with GI Lymphoma.
 

betsygee

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Update: He has completed the round of antibiotics and just started to eat on his own (nibbling). Hoping to get him to consume about 1/2 can of food per day by the end of the week.

Assuming his eating continues it will be a matter of seeing what happens when the steroid wears off in the next 2 weeks. If he relapses then we're dealing with GI Lymphoma.
I will be keeping my fingers crossed for his continued improvement!!! So glad he's eating on his own a bit.  And thank you for the tip about administering the metro at the back of the mouth.  I've been doing that with Molly and that allows her to keep more of it down and drool less.  :-)
 
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