Spoiling my kitten with myelodysplasia

ambernalbie

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Hello all, I am new to the forum, and in advance I greatly appreciate all the help I can get!

I adopted a 2.5 month old kitten (now called Albie) in February of this year from a cat hoarding situation. I got him neutered, vaccinated and chipped immediately, and he has been on a high quality diet since he joined my family; my boyfriend and our other cat, Babyman, who is just over one year old now (Also neutered, vaccinated and chipped!). The two young cats got along and played well. They have always been indoor cats because of where we live (Coyotes, bears, traffic, weather conditions).

In July, Albie got sick with a fever, diarrhea, vomiting, no appetite, etc. Took him to a vet, bloodwork showed exceptionally low neutrophils, x-rays showed no blockage. They tested him for the general feline virals, which we was negative. They gave him anti-nausea medication and fluids, we took him home and started clavamox, gave him pumpkin and monitored his temp. He got better after a few more days of fluids and care at the vets.

About 2 weeks later, the symptoms returned...and he returned to the vets office.... Again and again. To make a really long story short, this up and down continued for 3 months with several antibiotics, with no conclusive evidence to anything after x-rays, ultrasounds and bloodwork tests.

Terrified it was dry FIP (nothing on ultrasounds, negative parvo test, nothing on corona titer, no severe respiratory symptoms) or FeLV hiding in the bone marrow (negative blood test), I took him to UC Davis. After an exam, x-rays, ultrasound with aspirate of lymph nodes, bloodwork, bone marrow aspirate of BOTH shoulders, Albie was diagnosed with genetic myelodysplasia. He had zero neutrophils at the time. He was negative for FeLV from the bone marrow and highly unlikely FIP, which means the immunomodulators aren't an option.

Albie is currently on prednisolone, clavamox and baytril. His local vet offered some research from VIN regarding myelodysplasia and menatetranone, a vitamin k2 analog and its success in increasing neutrophils and other important blood cells. He is on 10mg of menatetranone a day along with his other meds. Right before he went to Davis, he had been sneezing off and on with no response to doxycycline or lysine. Per his vets, he is off of doxy but continuing lysine. Still no change in his sneezing. We do live in an older building with lots of dust, so I have an air purifier going 24/7.

A week after the Davis visit and starting the steroids, his neutrophils are up from 0 to 259. Normal starts at 2,500, but it's better than zero! We will be checking again this week.

And so, my little baby boy, who isn't even a year old, is basically a bubble boy. He continues to have a high quality diet; he is free fed Hollistic Select dry all life stages chicken formula mixed with Purevita all life stages dry chicken formula. He gets as much wet food as he will eat 2-3 times a day (with his meds) which is usually Fussie Cat, Tiki Cat, Solid Gold, Against the Grain, and occasionally a Fancy Feast Gravy Lovers or one with cheddar cheese, even though the ingredients are horrendous, because he loves it.

I want my Albie baby to enjoy his life as long as I can stretch it without him suffering. I was just hoping for some ideas on enriching his life within his limits, any ideas on making pilling easier, toys or food that any spoiled cat or kitten must have (He has Bonito Flakes, and plenty of them!), or any medical advice fellow kitty owners may have for these kind of situations.

Again, I appreciate any advice in advance, and if anyone has experience or questions on the matter please let me know!

Thanks,

Amber n Albie
 

ldg

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Apart from saying I am SO sorry for your Albie, I really want to say he's so very, very lucky to have been rescued and adopted by you. :heart2: :rub: :hugs:

For his pills, I assume you've already tried pill pockets? If he's a gobbler, and you haven't tried those, it's worth a shot. Ask the vet, but I don't think there are any pills in there that can't be broken in half (or quartered), and if I'm right, if he won't eat the whole pill in a pocket, but likes the pocket as a treat, you can try making the pill pieces smaller, and just tearing off a little bit of pill pocket to wrap around it.

As to the neutrophils... our Tuxedo had severe anemia, and we went through the same battery of tests, bone marrow aspirates, etc. He had a blood transfusion, and we almost lost him twice. His was ultimately classified an "autoimmune disorder," and in the end, depomedrol saved his life. Pred helped for a while, but then it stopped working, and the vet informed us he was "out of bullets." His hematocrit was 7 (I don't remember what his white blood cell work ups looked like, but they were quite funky along the way). He'd called feline blood experts around the country, and the only thing we hadn't tried at that point was depo instead of pred. And the mechanism of action was different enough that it worked. :)

BUT.... when his neutrophils were almost non-existent, our vet put him on Nupogen. (In fact, he was also on Epigen). Was this discussed as an option? :dk: He needed daily shots, I think it was, for a few months. Now, I realize his condition was completely different, but I put it out there....

For his quality of life? :D I have a cancer survivor. He was diagnosed with a very aggressive large cell lymphoma at the end of July 2011. We started chemo right away, and three weeks after then end of the six months of chemo, an ultrasound revealed his "massive" tumor (in his stomach) was in remission. And we just focus on doing anything he loves. He loves being brushed, he loves sleeping on my husband's legs at night, he loves playing with his feather wand toy, he loves freeze dried meat treats, he loves watching birds in the bird feeder we have stuck to the window.....

Just approach each day with your little boy as a gift, and pay attention to the little things he loves - and have fun figuring them out. :rub: :) Is it sneaking a lap of strawberry ice cream from your spoon? Is it drinking water from your glass when he thinks you're not looking? A new paper bag? A box castle? (Large boxes, scissors (or a box cutter) and duct tape!) For our Tuxie (the one with anemia), it was warm jumbo shrimp shredded in a bowl. :lol3:

My thoughts, vibes, and best wishes are with you.... :vibes: :vibes: :vibes: :vibes: :vibes: :heart2:
 
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ambernalbie

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Thank you so, so very much for your response!

We used pill pockets with great success for a few days before he figured out what was going on and stopped eating them even if they were empty! I've been dipping the pills in tuna juice or a little bit of butter to make them go down easier, which is working for now.

I will certainly follow up with my vet about the drugs you mentioned, it can't hurt to at least look into them! I think I read your thread about Tuxie from awhile back, it sounds a little familiar...

Thank you also for the ideas- funny enough, he has several paper bags and box castles, and we've constructed our couch into a kitten fort! I will definitely be watching and listening to him to see what else he might be interested in...
 

Thank you again so much for the info, and the kind words and thoughts! I can tell all your kitties are blessed to have you too!
 

ldg

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:hugs: :hugs: :hugs:

There may be a reason Nupigen wasn't brought up, but since he's apparently capable of making neutrophils, it's certainly worth asking about. It is an injection. We can administer sub-q fluids, but we couldn't bring ourselves to do that. It was daily trips to the vet. (In fact, we actually ended up moving so we would be closer to the vet).

And if the prednisone is working, great. :nod: But just keep it in the back of your mind that the depomedrol shots may work if it doesn't. :hugs:

Aw, he's living in kitten dreamland! :clap: :clap: :clap:

Care to share a picture of your kitties - especially your little Albie, so we know who we're sending vibes to? TCS has some pretty powerful magic! I hope it helps. :heart2:
 
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ambernalbie

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Put up some pics!

Thanks again for your input, I think we are gonna like this place!
 

Christy and Fido

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Hello,
Thanks for having me on the site. My Fido, is a 17 1/2 yr old tortie point....
As of this moment, she has one potential diagnosis of MDS, and one of Leukemia ( pending results of bone marrow slides at CSU)

This discussion was really interesting and I'd like to bring up a few of these treatments to my IM vet but would like more info if you have it.

Fido had way elevated blood sugar after 12 days on Pred and now her IM vet wants her tapered off of it... that you mention there may be an alternative is music to my ears.

What does dopemedrol do, and what does Nupogen do? ( Darbopoitin Alpha failed for Fido after a short period of time - something in her marrow is destroying her blood cells ) Currently she is transfusion dependant ( still happy when she has a refresher of blood) and they are lasting only 2 weeks.

I'd really appreciate knowing how your kitties did on these meds ( the v K analog, dopemedrol and the nupogen - and if they were all used together?)

Thank you so much,
Christy and Fido

These pics were from a couple days ago - she is shaved because of BMB on her shoulder, and of course the "socks" are from hospitalization and bloodwork, but she is happy in the sun, and still "my Fido" inside :)
 

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