Cat pee'd on couch mixing cleaners okay?

You can use Anti-Icky Poo on top of Nature's Miracle. They're both enzyme cleaners (it just really gets hard when you set the urine with a regular household cleaner - because that's all they do. Soap & water didn't detract from what the enzyme cleaners will do, however). Trust me, Nature's Miracle won't do it. And you'll probably need to treat it at least once more, if not twice.

Things like a couch and mattresses are harder than floors because of that third dimension - depth. We had a kitty with a problem that peed on the couch several times, and it always took 3 treatments to get the smell out. The problem is that cat pee wicks, and to get the smell out, you have to get the enzyme cleaner to all the same places the cat pee went. So you have to really soak it - and even then, you don't necessarily get the enzyme cleaner to all the same places on the first go round.

Our kitty peed on the cushions, and it didn't make it down to the frame. We tried pouring the enzyme cleaner on the cushion - in the end, we really had to soak it. I'm not quite sure how we had to use about gallon of enzyme cleaner to clean up what must have been a cup or less of cat pee LOL, but .... the bottom line is that spraying the surface won't do it. You have to get it down in there. And if you do it right - it can take days to dry (especially if it's humid).

But if you want to get at it with the Nature's Miracle while waiting for the Anti-Icky poo, you won't make the Anti-Icky poo less effective.

The quart may do. It'll certainly be enough for the first treatment. I've never used Anti-Icky Poo, and it's supposed to be fabulous. So it may work with one treatment, especially as you have syringes to help get down in there!

BTW, bleach wouldn't work either. Happy to provide a link to a lot of detail on the issue of cat pee and smell, if you're interested. The bottom line is that enzyme cleaners are the only way to permanently get rid of the smell.

Apparently the original post was here in the behavior forum, but I found where I provided the information to someone else: Why an enzyme cleaner is the only thing that ultimately works to remove the smell of cat pee

Good luck!

I used oxy clean on the couch where my boy once peed. i saturated it about 3-4 times over 48hr period, and using one roll of paper towels, un-rolled, just pressed against the spot to draw out the liquid. Took about 1/3 of the bottle of oxy clean and 2 rolls of paper towels. Now both my cats love to sleep on the same cushion!... no problems, no smell what-so-ever.

now, a warning that spot is lighter in color, by about 1-2 shades that rest of couch. I imagine because of the oxy clean's special chemicals.

OxiClean is primarily sodium percarbonate, which is sodium carbonate and hydrogen peroxide. Hydrogen peroxide has 30x more oxidizing ("bleaching") power than chlorine, which is why that spot is lighter in color.