I recently bought the large dog size of advantage and I can treat all my cats and 2 dogs with one tube, I just use one of those plastic bathroom cups and drop in about 9 or ten drops and syringe it up into a syringe and it comes to the .4 mil mark and use it that way. It saves me so much money since I have so many cats and dogs and my vet says Advantage is the same product for dogs and cats, theres no difference. But I think that may be only the Advantage though, I dont know about other products like Frontline. I was really nervous about doing it this way and I asked my vet and she said it would be fine to do it this way to save money. Just make sure you get the small syringes, they work the best if you do it and tape the mark where you want the dosage to be because it desolves the marks on the syringe. Oh and make sure you throw the cup out and when you get done, wouldnt want anyone to take a drink out of it by accident.