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Starting a Prednisone Trial..

post #1 of 27
Thread Starter 
Well anyone who ever paid even a tiny bit of attention to any posts about Genever will know that she pukes kind of a lot. And we don't know why. Tried many things, different foods, elevated dishes, ping pong balls in the dish, but she'd puke sometimes even after only about 10 pieces or 1 forkfull of food, so I don't think it's scarf-n-barf. We tried Pepcid AC, Reglan, Sucralfate, a shot of Cerenia, an x-ray, nothing changed anything or showed any problems. She has lost some weight since about a year ago around when she started to puke a lot. She was 11.5 lbs, and has hovered between 10-11 since then. Otherwise she seems perfectly normal and healthy.

I (and the vet, too, it seems) refuse to just accept that some cats just puke a lot, a lot being sometimes every day for a few days, then not again for 5 days, then maybe in 2 days and twice the next day, then a week before the the next puke, etc. Frequent but inconsistent.

So the latest attempt to stop this is now we're going to try Prednisone to see if it could be inflammation related to IBS. (or is it IBD? Sorry, my brain isn't working. Something about inflammation and bowel.) I'm picking up the pills and instructions this afternoon, the vet said we'll try a tapered dose over at least 4 weeks to see if there's any change. I really hope this does the trick, because even though I hate prednisone (i take it myself), I know a small maintenance dose can do wonders (again, I take it myself).

Those of you with cats on prednisone, anything you can add that I should look out for or hope to expect?

Thanks, and please wish us luck with this and hope that we don't have to go the next route - $300 ultrasound, which may or may not turn up anything.
post #2 of 27
Aside from pred, I would put her an a allergenic or LID diet to rule out food allergy/sensitivity related inflammation (which can be a trigger for IBS and sometimes a cause for IBD, although there are many possible causes for the latter, food being only one possibility). What is she eating? In Bugsy's case, The vet believes his immune-system related, and completely independent of food, which also explains his stomatitis...

Pred worked very well for Hope who has IBS - we did 30 days to control the inflammation, and then phased her off of it and now she has it under control with diet alone. The Dr. also had her on Amforol for Vomit/Diarrhea as needed (NOT for cats with Kidney disease). It works very well. But he only did this because she was an extremem case, she was doing really bad... I am not sure how much Genever is throwing up... If a lot, you might want to discuss it.

Oh, I should say, Hope is 100% better- BUT she cannot get out of her diet, AT ALL.
Pred works really well. I do not like for long term treatment, and would try to go without it if possible. If not possible, I would use the minimum dosage necessary, and be closely followed by the vet with periodict bloodwork to check for side effects.
Good luck
post #3 of 27
I have three on it currently for respiratory inflammation, it stopped the coughing quite quickly and they're all breathing a better.

I hope that you see a quick reduction in Genever's vomiting, too.

It's given a bad rap because of it's side effects, but if it works than it works. My male kitten is eating with a decent appetite finally - whether that is the pred or just because he feels better, I'm not sure.

for Genever, you've been through a lot with her.
post #4 of 27
Thread Starter 
Quote:
Originally Posted by Carolina View Post
Aside from pred, I would put her an a allergenic or LID diet to rule out food allergy/sensitivity related inflammation (which can be a trigger for IBS and sometimes a cause for IBD, although there are many possible causes for the latter, food being only one possibility). What is she eating? In Bugsy's case, The vet believes his immune-system related, and completely independent of food, which also explains his stomatitis...

Pred worked very well for Hope who has IBS - we did 30 days to control the inflammation, and then phased her off of it and now she has it under control with diet alone. The Dr. also had her on Amforol for Vomit/Diarrhea as needed (NOT for cats with Kidney disease). It works very well. But he only did this because she was an extremem case, she was doing really bad... I am not sure how much Genever is throwing up... If a lot, you might want to discuss it.

Oh, I should say, Hope is 100% better- BUT she cannot get out of her diet, AT ALL.
Pred works really well. I do not like for long term treatment, and would try to go without it if possible. If not possible, I would use the minimum dosage necessary, and be closely followed by the vet with periodict bloodwork to check for side effects.
Good luck
Thanks for all that. We tried NB Duck & Green Pea ONLY for about 2 months, with no change. So then I added back some Wellness cans, because she likes them better and kind of stopped eating duck & pea cans. She still eats Duck & Pea dry though and loves it. As I said, G-cat throws up, well, it's hard to say how much or how often. As of today, Tuesday, she hasn't puked since Friday night. Before that she puked Friday morning. There is just no pattern to it, other than it's usually shortly after she eats. I keep a journal, and I see no connections with food or change/stress or anything. She's been to the vet quite a few times over the past year because of it. It's frustrating. I want her to be well!

Quote:
Originally Posted by strange_wings View Post
I have three on it currently for respiratory inflammation, it stopped the coughing quite quickly and they're all breathing a better.

I hope that you see a quick reduction in Genever's vomiting, too.

It's given a bad rap because of it's side effects, but if it works than it works. My male kitten is eating with a decent appetite finally - whether that is the pred or just because he feels better, I'm not sure.

for Genever, you've been through a lot with her.
Thanks, we have been through a lot, but I'm probably paranoid too so maybe I make it out to be more than it is, whatever is wrong with her at the time.. I just know that when I throw up, it's not pleasant, so I'm sure Genever doesn't enjoy it either. My poor Little Miss Pukey!
post #5 of 27
I feel your pain! Franklin was a frequent puker. Sometimes once a week, sometimes every day. We tried every food known to man and nothing helped. He couldn't keep weight on. As a last resort he had intestinal biopsies which confirmed IBD, inflammatory bowel disease. He started a prednisolone regimen. Prednisone is converted into prednisolone in the liver and some cats don't do that conversion efficiently. Son you might ask your vet about going right to prednisolone. Franklin started with 5 mg twice a day for 4 weeks. Then he got 5mg once a day for 4 weeks and then 5mg once every other day. This is where he is now, and will be for life. The results have been nothing short of a miracle! He took his first dose on May 23 of this year and hasn't puked since! He is up to 8 pounds from 6 and has never looked better. His b12 levels wer loa so he got 10 weekly injections of b12. They are easy to do and I did them at home. Good luck. There is light at the end of the puking tunnel
post #6 of 27
Thread Starter 
Thanks KyleW. Actually when I went to pick up the pills, I saw it actually is Prednisolone, 5mg. I gave her the first pill this morningin a pill pocket. I am to give Genever 1 pill everyday for 2 weeks, then a half pill everyday for 1 week, then a half pill every other day for the next week and a half or so and call the vet to discuss. I hope this works!!
post #7 of 27
So she likes the pill pockets?

I hope it helps. Keep us updated, I would love for some sort of resolution to be found for Genever. IMO if it's going to help you should see some result within the next few days.
post #8 of 27
I'll keep my fingers crossed for you. As stange wings said you should start seeing results immediately. Franklin hasn't puked since the first pill! If it does for Genever what it did for Franklin you will both be much happier
post #9 of 27
Thread Starter 
G-cat loves pill pockets. So it makes all our lives so much easier. The one thing she really seriously fights us on is getting pills shoved down her throat, which is understandable, but she gets this strength from nowhere! When she had giardia, those pills were so bitter I guess that she wouldn't even take them with a pill pocket after 1 day, so we had to do it the hard way. It was not fun. Everything else has gone in a pill pocket though, I even got the Duck & Pea allergy formula back when we were doing only the duck & pea food and giving her Pepcid.

Nice to know also that if this will help, it will help quickly. She still hasn't puked since Friday night, but she has gone a week or so between pukes sometimes in the past, so if I get past the weekend and still no puke, then that will be a very good sign. Since it's so inconsistent, the vet told me instead of counting the times per week, to instead count the times per month during this trial and compare with past months. I have a year or so of records in my little notebooks..

Thanks for your concern and insight. I will keep you posted.
post #10 of 27
Hmmm....sounds like life with Eden! She would throw up a lot, her coat was dull, she shedded a ton, and wasn't very active. Several vet visits, blood panels, tests, etc - nothing wrong with her. The vet did NOT want her on Pred b/c of her past history.

So we tried diets. I discovered she cannot eat dry food at all within 1 hour before or after getting wet food. She is eating mostly Natural Balance Green Pea & Chicken formula - the other two LID formulas didn't work for her. I added in Pro Plan Sensitive Skin & Stomach formula about 2 months ago....and since then the vomiting is gone, her coat looks great, & she's a playful little booger (she likes to grab ankles & have you drag her around). So after almost 2 years of problems with Eden, her diet, & digestive tract we're finally walking on solid ground (or puke free carpeting, however you wish to think about it ).
post #11 of 27
I've been wondering how Genever is doing, and will be watching for updates on how the prednisone is working for her.

Two things I know about prednisone: increased appetite and increased urination. Oh and it does have to be tapered off, not stopped suddenly.

Please keep us posted on dear Genever.

Genever!
post #12 of 27
Thread Starter 
Quote:
Originally Posted by white cat lover View Post
Hmmm....sounds like life with Eden! She would throw up a lot, her coat was dull, she shedded a ton, and wasn't very active. Several vet visits, blood panels, tests, etc - nothing wrong with her. The vet did NOT want her on Pred b/c of her past history.

So we tried diets. I discovered she cannot eat dry food at all within 1 hour before or after getting wet food. She is eating mostly Natural Balance Green Pea & Chicken formula - the other two LID formulas didn't work for her. I added in Pro Plan Sensitive Skin & Stomach formula about 2 months ago....and since then the vomiting is gone, her coat looks great, & she's a playful little booger (she likes to grab ankles & have you drag her around). So after almost 2 years of problems with Eden, her diet, & digestive tract we're finally walking on solid ground (or puke free carpeting, however you wish to think about it ).
For a few weeks or so, way back when, I didn't feed Genever any dry food at all, thinking that was the problem. The result- puke puddles instead of piles. One thing I did notice during different food trial periods is when she was strictly on NB Duck & Pea, her coat got a bit dull and felt not as soft. When I added Wellness cans back in with the Duck & Pea dry, she got soft again.

She has had 2-3 itchy skin issues since we got her, but it doesn't last long, I give her 1/2 a chlor-trimeton allergy pill (approved by the vet) for a few days and it clears it up.

By the way, after we adopted Genever in Jan 2009, she had giardia but we didn't realise it for a few months, we just thought she was just a really stinky cat when she pooped. (bad cat owners!! I'm so sorry g-cat! I'm a hypochondriac for you now!) And since that got taken care of, her poops are all normal. It's just the upper part of her digestive tract (maybe) that is the problem here.

Why can't there be one right formula that works for all cats on the planet??
post #13 of 27
for G-Cat! I hope this medicine helps her feel better!
post #14 of 27
All paws crossed here, too, that the pred works for Genever. Our Rainbow Banshee was on prednisone for about 4 years for asthma problems. She took 1/2 of a 5 mg pill every other day.

We have two pukers in our house. And honestly, we've tried anything and everything. We are now putting two drops of Mylicon in the water dish. They still puke, but we have found that it's not as often as it used to be. The vet was wondering if they had gas from gulping their food....and they are gulpers, too. My GF suggested Mylicon and it might be helping the two Old Crabs.

Good luck with Genever!
post #15 of 27
Quote:
Originally Posted by DarkMavis View Post
Thanks KyleW. Actually when I went to pick up the pills, I saw it actually is Prednisolone, 5mg. I gave her the first pill this morningin a pill pocket. I am to give Genever 1 pill everyday for 2 weeks, then a half pill everyday for 1 week, then a half pill every other day for the next week and a half or so and call the vet to discuss. I hope this works!!
No advice about the puking or diet issues, but Riley was on prednisolone off and on for nearly a year for his asthma. Its good that she likes the pill pockets

Also, I have no facts or information regarding this, but for some reason I noticed that Riley did better when taking his pill at night after dinner, rather than in the morning. It just seemed to decrease his behavioral side effects (a bit of aggression) and when he had it in the morning he was also a bit more lethargic through the day. Like I said, no idea why this would be and maybe it was only Riley, but it helped a lot to give him the pill at night.

He did put on some weight, but I gather that would be a good thing in your case!
post #16 of 27
^Thank you for that input. Mine are still on 2x a day but will go down to 1x day. I've notice no behavior issues so far, only that Blann can actually behave like a cat now.
post #17 of 27
Thread Starter 
That's interesting that you noticed better results with giving the pred. in the evening. I just thought I'd do it in the morning because I know when I started taking prednisone about a year ago, I had taken it at night ar first and then I was up all night, I really had trouble sleeping. So I now take it in the morning instead. So from that, I thought if Genever has hers in the morning, then maybe she'll be more active in the day and not so much at night? I don't know. The past 2 days she's pretty much the same as usual, behavior-wise. Active in the morning, sleeping in the afternoon, active in the evenings and at night (running laps and chasing ping pong balls all over the place).

I have noticed today that there were more pee clumps in the litterbox. Haven't seen any difference in eating really. She eats a good amount usually I think, though she doesn't eat 'meals', she picks all day long. And that will be another topic for another thread very soon about what happens when we adopt another cat (probably in the very near future)- what if it does clean its plate at meal time? Will it clean Genever's too? Or will she learn to eat better? sigh...

Still no pukes since Friday night- almost a whole week! Hope it keeps up!
post #18 of 27
A whole week! Congrats I read some place that when you get down to the every other day maintenance dose it is more advantageous to give it in the evening. It has something to do with their "biorhythms".
post #19 of 27
Quote:
Originally Posted by KyleW View Post
A whole week! Congrats I read some place that when you get down to the every other day maintenance dose it is more advantageous to give it in the evening. It has something to do with their "biorhythms".
Interesting! Maybe that's the problem Riley had? May have to see if I can find an article or something about this.
post #20 of 27
Glad to hear Genever is doing okay so far on the pred. Will be watching for updates.

My cats are, have always been, schedule fed, so bringing in a newbie is not ever a problem in the feeding department. Hopefully your newbie will be a self regulator and you will be able to continue to free feed.
post #21 of 27
Thread Starter 
Quote:
Originally Posted by otto View Post
Glad to hear Genever is doing okay so far on the pred. Will be watching for updates.

My cats are, have always been, schedule fed, so bringing in a newbie is not ever a problem in the feeding department. Hopefully your newbie will be a self regulator and you will be able to continue to free feed.
I feed Genever on a schedule, it just takes her a long time to finish her meals, so it turns out to be more like free-feeding/grazing. She eats a few bites, walks away, an hour or 2 comes back for a little more, etc. So if Miss New Cat eats a meal, then.... hopefully she won't eat Genever's meal too, or maybe Genever will learn to eat properly if she wants to have any food left!

We very well may find this out by next week actually, I was so tempted to come home with one this past Saturday..

Also... STILL NO PUKE! It's been 10 days now!
post #22 of 27
Quote:
Originally Posted by AlleyGirl View Post
Interesting! Maybe that's the problem Riley had? May have to see if I can find an article or something about this.
I found the article that mentioned evenings. Here it is.
post #23 of 27
Thread Starter 
OK, well since I have been giving the pill to Genever in mid-morning, how can I switch it to the evening? Would it work just gradually over a week or so, giving it an hour or 2 later each day until I'm giving it to her at night?
post #24 of 27
That would work, if you are around to do it. I wasn't so I doubled up one day. His 48 (or 24) hour pill was in the morning and I gave it to him. Then I gave him another that evening. I figure more was better than less and I didn't have to worry about gradually increasing the time between pills.
post #25 of 27
Thread Starter 
OK then I will give her a pill tonight and continue to give them at night, and hopefully it will be better for her. Thanks for the info!!

I really hope she continues to not puke when I start to taper the dose... It will be so wonderful for both of us for her insides to be better!!
post #26 of 27
Quote:
Originally Posted by DarkMavis View Post
I really hope she continues to not puke when I start to taper the dose...
Franklin hasn't puked since May 23rd and he's down to every other day!
post #27 of 27
Quote:
Originally Posted by KyleW View Post
I found the article that mentioned evenings. Here it is.
Thanks!

Wish I had known that when Riley was first on it. I just noticed the way he was acting and decided to try it at night, with noticeable difference. Good to know there is a reason for it.
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