Related Cats Attacking Each other

Let me give you some background. I have 3 cats. One is the mother who i took from the streets, she is about 4 years old, she is the nicest cat i have ever had, never hisses, never scratches, all love. I brought her in 2 years ago and she had a litter of kittens. We (Me and my girlfriend) kept two kitten, one male and one female. All of them are spayed and neutered and declawed. The male one is kinda a crazy cat, runs alot and makes crazy noises. Not particularly aggressive, sometimes he likes to attack his sister but it seemed more like playing. The female kid has always been kinda angry. never let me r my girlfriend ever touch her, and she always hissed at me. she hides alot and we see her like 5 minutes max a day. Like i said before the male cat likes to chase her a little and play and once or twice looked like he tried to mount her, but she always batted him away or meowed him away. and then that was it. they were fine like 10 minutes later. And sometimes the male cat would curl up next to his mom (He was always kinda a mommas boy) and sleep near her or get a bath, and if she didnt feel like it she hit him in the head and he would admit defeat or run away. Never a problem. But at 6 this morning i was awoke to the loudest meow i ever heard. I thought the male cat and the sister were going at it and i was prepared to stop it. but i look and the sister cat is in the kitty bed and the mom and son are in my room staring at each other and hissing and meowing. This has never happened before and right now the male cat seems afraid of his mom, a few minutes ago i cam in and she followed and he meowed even louder then before and started hissing and was looking for an escape. What could cause such a change? they always loved each other and now they are fighting and now none of them are coming out of my room. The mom is at the top of the bed and the other two are in a corner near the tv. What should i do?