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Is this arthritis? Or something worse??

post #1 of 26
Thread Starter 
Hi all,

I've noticed lately that Waggles is lying with his front paws really curled under. Not like cats usually do, but imagine bending your wrist down towards your arm until it touched. I'm including some photos that I hope show what I mean (he did move when I started fussing with him). It doesn't appear to cause him any pain as I've felt all over his paws and legs and he doesn't flinch. It does bother him in the sense that when he stands up after he's been lying a while the wrist joint doesn't want to fully support him and it 'kicks' out a bit.

Waggles has bad arthritis in his back end and we recently started Adequan injections (he's had 2) and is going for his next one in 2 days. I plan on discussing this with my vet then but I was just wondering if anyone else has noticed this in their cat. Is it arthritis or some type of injury? It happens with both wrists. I read something about tendon injuries in cats but he doesn't jump at all so I don't think he could have injured himself.

Thanks,
Dolly



post #2 of 26
Geez, I sure don't know. Anyway you could print off or email those pics to the Vet, for him to see?

Is kitty declawed at all?
post #3 of 26
It look like a sprain or injury but I really don't know
Poor cat
post #4 of 26
Poor thing! I think a trip to the vet to find out what's going on is in order.
post #5 of 26
Quote:
Originally Posted by stephanietx View Post
Poor thing! I think a trip to the vet to find out what's going on is in order.
How is he/she today? Is he fine or getting worse ?
post #6 of 26
I'll be interested in hearing what your vet thinks about this.

I'm also interested in how Waggles does with the adequan injections. When Ootay (rb 5/09) was suffering so much with arthritis pain my vert and I discussed adequan, but I opted against it, after reading how painful the muscle injections are, she was so fragile already.

Now I know that it's been discovered that the injections are just as effective being given subcutaneously, so I will definitely be considering them for my next kitty with severe arthritis problems.

Please do let us know how Waggles is doing.
post #7 of 26
Thread Starter 
Thanks for the input and support. I took Waggles to the vet yesterday and my vet said she thinks it's a neuropathy. The curled wrists isn't typical of arthrtitis.

We immediately re-checked his blood glucose as neuropathy is most commonly associated with diabetes in cats. He glucose was fine and it has always been normal. So it's not diabetes. He also has CRF and his recent bloodwork showed his potassium and phosphorus are also fine (which could contribute to muscle wasting).

My vet says it's basically an idiopathic neuropathy which can happen in particular in older cats, it's degenerative nerve damage. We don't know how old Waggles is as he was rescued as a stray but I'd say he's probably 15 anyways. She suggested methylcobalamin (B12) which has been shown to be successful in treating neuropathy in cats and people. I had been giving him this but not enough. B12 is safe to give as the excess is urinated out, so he's getting 3 mg a day. I'm keeping my fingers crossed that we'll see some improvement with this.

As for the adequan--I think it has been helping as his back end seems to be more comfortable, before he would snap at me if I even petted him there but now he seems to be more comfortable and is sitting up straighter. Waggles is generally grumpy at the vet but he literally didn't even move when she gave him the injection--I don't think it hurt him at all and he didn't show any ill effects afterwards.

The adequan won't help the neuropathy though so I'm really hoping the B12 will help.

Dolly
post #8 of 26
Hopefully the B 12 will help. It should. Based on the info below, has thyroid function been checked? Can hyperthyroidism be ruled out as a possible underlying cause?

http://www.vetinfo.com/feline-neurop...cobalamin.html

Quote:
The most commonly known feline neuropathy is feline diabetic neuropathy. Neuropathy is also seen in cats suffering from hyperthyroidism.
post #9 of 26
Thread Starter 
Thanks Violet, his thyroid was also checked in January and it was 12.6 (normal 11-46, metric units of nmol/L which converts to 0.98 in US units) so he's actually on the low end of the scale. I'm not sure if this could be a cause or not, my vet didn't mention it. I think certain drugs can lower the T4? Waggles is on several meds. for CRF and pancreatitis.
post #10 of 26
Thanks so much for the info you've just shared. So I'm looking for answers. Not done yet, but so far this is what I've found. (In humans) among a list of conditions, neuropathy can be associated with hypothyroidism, arthritis and B 12 deficiency.
The list of medications (for humans) that can cause neuropathy is practically endless. The question is whether some of these meds (some antibiotics and metronidazole for instance) can cause the same side effect in cats.
Medications that can interfere with thyroid function (in humans) include sucralfate and some antacids. Also, high doses of steroids, etc. I don't have the detailed info I'd like on this just yet, but from what I've found so far, possible side effects of different meds in general would be worthwhile to think about. This is an area where many medications have not been studied extensively and so their side effects in animals are not known.

May I ask what meds you're using for the CRF and pancreatitis? Also, are you using any herbal or other natural remedies?
post #11 of 26
Quote:
Originally Posted by Violet View Post
Thanks so much for the info you've just shared. So I'm looking for answers. Not done yet, but so far this is what I've found. (In humans) among a list of conditions, neuropathy can be associated with hypothyroidism, arthritis and B 12 deficiency.
The list of medications (for humans) that can cause neuropathy is practically endless. The question is whether some of these meds (some antibiotics and metronidazole for instance) can cause the same side effect in cats.
Medications that can interfere with thyroid function (in humans) include sucralfate and some antacids. Also, high doses of steroids, etc. I don't have the detailed info I'd like on this just yet, but from what I've found so far, possible side effects of different meds in general would be worthwhile to think about. This is an area where many medications have not been studied extensively and so their side effects in animals are not known. So so true ... even in humans many side effects are found out years after the drug is released.

May I ask what meds you're using for the CRF and pancreatitis? Also, are you using any herbal or other natural remedies?
Along the above lines... I dont feel like writing out the PDR tonight on the list of meds with this side effect known in humans..

here is a article on basic in cats
http://www.vin.com/VINDBPub/SearchPB...00/PR00325.htm

http://www.ehow.com/about_4605461_fe...europathy.html
post #12 of 26
Thread Starter 
Thanks for looking into this Violet, I really appreciate it. Waggles gets the following:
1/8 pill zantac 2x/day (total pill=75 mg)
1/4 ondansetron/day (total pill=4 mg)
1/2 Fortekor/day (ACE inhibitor)
5 mg prednisolone every other day
potassium gluconate supplement
sub-q fluids every other day
now 3 mg B12 methylcobalamin/day

I had been giving him 1 mg B12, but started him on 2.5 mg about 3 weeks ago but that doesn't seem to have helped yet--at least not with his front paws. If anything it seems to be getting worse. His back legs though seem to be a little better, he isn't walking on his hocks as much. After seeing the vet yesterday I'm going to 3 mg and might go higher since it can't hurt him.

Any idea how long it might take for the B12 to help?

This has me quite concerned. With everything else going on, I would hate for this to ruin his quality of life.
post #13 of 26
Be careful the link I gave you above states b12 and what should not be done... Personally I have seen a b12 SHOT work very well with accupucture in a semi paralyzed animal

some ideas to discuss with a vet...
http://www.merckvetmanual.com/mvm/in...%2cinvolvement

Read the below link first it may help more than the above
http://www.merckvetmanual.com/mvm/in...%2cinvolvement


http://www.merckvetmanual.com/mvm/in...ch/advsrch.jsp
post #14 of 26
Spookzilla, hi again. Thanks so much for the list of meds. I have one more quick question, hope you don't mind. When was the last time blood potassium was checked and would you happen to know what the value was at that time?

According to Vetinfo
http://www.vetinfo.com/feline-neurop...cobalamin.html

Quote:
Methylcobalamin Supplementation

Methylcobalamin is a form of vitamin B12 that contains the mineral cobalt. Deficiency of B12 leads to nerve damage, anemia and gastrointestinal problems. The supplement is given in a dosage of one 3 mg tablet, once a day. Methylcobalamin tablets successfully treat the symptoms of feline diabetic neuropathy in a short period of time. Although neuropathy is cured once the diabetes is regulated, administration of methylcobalamin supplements aid in faster recovery.

The reason for tissue repair due to methyl-B12 supplements or methylcobalamin is not well established. Research indicates a link between specific nerves deficient in methyl-B12 and neuropathy or nerve damage.

So if this will work, you should see results very soon.
post #15 of 26
Quote:
Originally Posted by Violet View Post
Spookzilla, hi again. Thanks so much for the list of meds. I have one more quick question, hope you don't mind. When was the last time blood potassium was checked and would you happen to know what the value was at that time?

According to Vetinfo
http://www.vetinfo.com/feline-neurop...cobalamin.html




So if this will work, you should see results very soon.
http://www.ehow.com/about_4605461_fe...europathy.html This link states up to a year .. Yet another lovely thing the experts cant seem to agree...

I have seen a b12 SHOT used for this issue work within a few minutes( since acupuncture was stimulating it like a bit of a quicker result...
post #16 of 26
PS:

Sorry, one more question, a very important one. How high is phosphorus?
Do you have a recent value?

And a question about the sub-q fluid you're using. Is it lactated ringers solution or saline solution?
post #17 of 26
Quote:
Originally Posted by Violet View Post
PS:

Sorry, one more question, a very important one. How high is phosphorus?
Do you have a recent value?

And a question about the sub-q fluid you're using. Is it lactated ringers solution or saline solution?
Great ?s ....
post #18 of 26
Thread Starter 
Thanks again Sharky and Violet for your input and questions. His potassium and phos. have always been in the normal range. His most recent values (Jan. 23) are

potassium 4.6 (3.7-5.8), has ranged from 4.4 to 5.0 since CRF diagnosis in Sept. 08
phos. 1.5 (0.8-2.5), has ranged from 1.2 to 1.8 since Sept. 08 (sorry these are Canadian values)

His sub q is lactated ringers, 100 ml eod.

I see the vet again next week for another adequan shot. Maybe I will mention the B12 injection idea.

thanks,
Dolly
post #19 of 26
Thanks again, Spookzilla. These numbers look good. Not out of range, not even too high or too low. Everything seems to be under control. Also, going by these numbers, clearly, nothing on the list of meds is causing an imbalance that in turn would cause muscle weakness. (That was one possibility I was worried about.)

Lactated ringers is a very good, safe choice for sub q fluid, so again, I'm relieved. All this is very good.

I would also urge you to give B 12 injections a try. There are times when bypassing the stomach is very helpful. In injection form absorption of the vitamin is infinitely better and so treatment is more effective. You can't go wrong if you try the injections. And they are as easy to give as the sub q fluids, so no problems even with that.
post #20 of 26
Thread Starter 
Thanks Violet, is the injectable B12 the methyl or cyano form? Is is only available from the vet or can it be ordered online?

Would the cyano form help at all in this situation, or is it primarily for malabsorption issues?

One other thing I forgot to mention is that Waggles has been on a 6-week course of baytril for a suspected infection (his Jan. 23 bloodwork showed elevated white blood cells and pancreatitis). He had been showing more signs of nausea when we did the bloodwork. Fingers crossed I think the infection may be under control as he seems to be feeling much better and is eating well, but now that I think of it the curled wrists has just started in the past few weeks. I don't necessarily think that Baytril itself would cause it, but it does make them drink and urinate more, so could he possibly be losing more B12 from that? Just a thought.
post #21 of 26
Methylcobalamin comes only as oral medication. Cyanocobalamin is the injectable form.

The reason I would want to try this is because you're not dealing with diabetic neuropathy here. The simple underlying cause may just be a B 12 deficiency, or it could even have something to do with the arthritis. For other possibilities I would ask an orthopedic specialist. (Your vet could do that for you.) Anyway, there is a question whether using the methyl form is indeed essential in this situation. It very well may be. So I would ask the vet if it would be all right to use the oral form as well while trying the injections. Since there is no danger of overdose and B 12 is essentially non-toxic, there would be nothing to worry about.

I would also ask the vet to get in touch with an orthopedic specialist to find out if Baytril could possibly have anything to do with neuropathy. An orthopedic specialist would be my trusted source for this information.
Actually, I'm wondering, would you have access to an orthopedic specialist in your area so Waggles could be seen for an evaluation? It would be wonderful if you could do that.

I would get the injections directly from the vet if your hospital has a pharmacy, or from a local pharmacy. I would not get them online. You wouldn't want more than three anyway, to start with.
post #22 of 26
What is the difference in therapeutic value:pills vs shots?

I gave my Ootay subq B-12 and B complex shots, and they did very well for her. When first starting I noticed the full benefit by the third day after the shots, and benefits lasted about 10 days total.

Ootay had CRF, high blood pressure (untreated) hyperthyroid (untreated) megacolon, heart murmur, arthritis and stroke (from the untreated HBP and HTD)

She did not have high phosphorous, and her potassium was normal, though she did walk on her hocks. That hock walking did seem to improve slightly after the B 12 and B complex shots, but it was hard to tell after her second stroke, since she had some permanent paralysis. She could still walk, and was not in pain from it, but her little body went in kind of a U shape.

Yes, the solution in the injections is very sensitive to light and does not have a long shelf life, so you can't really get more than two or three in advance at a time.

Please keep us posted on Waggles!
post #23 of 26
Thread Starter 
Thanks Otto and Violet, I think the orthopaedic specialist is a good idea and I will definitely ask my vet about B12 injections.

Otto, my understanding is that oral B12 is not absorbed into the body as readily as injections are so if you are giving them 3 mg orally then the body will actually only use a fraction of that. With injections the body uses a lot more of it.

Were you giving Ootay the cyano form of B12 only or the methyl form?
post #24 of 26
Quote:
Originally Posted by spookzilla View Post
Thanks Otto and Violet, I think the orthopaedic specialist is a good idea and I will definitely ask my vet about B12 injections.

Otto, my understanding is that oral B12 is not absorbed into the body as readily as injections are so if you are giving them 3 mg orally then the body will actually only use a fraction of that. With injections the body uses a lot more of it.

Were you giving Ootay the cyano form of B12 only or the methyl form?
I don't know. I didn't know there were different forms of the shots, I only know that one shot was strictly B-12 and the other was B-complex(all the other Bs) One was pink and one was yellow, but I don't remember which was which.

I can ask my vet next time I am there, which will be at the end of March.
post #25 of 26
Pill has to be fully Digested prior to absorption ... Liquid ie shot is strait into the bloodstream no digestion required... Red / pink was the B12 likely at least that is the color of the one my vet uses

IMHO I have always done liquid or subliminal for myself ( I can say for this human with nerve issue this and another natural supplement helped MORE than a potent rx).... I took regular tablets with no results
post #26 of 26
Quote:
Originally Posted by spookzilla View Post
Otto, my understanding is that oral B12 is not absorbed into the body as readily as injections are so if you are giving them 3 mg orally then the body will actually only use a fraction of that. With injections the body uses a lot more of it.
That is what my vet told me. Nabu is on B12 injections and they really help. He's on it to help with his digestive issues. Cosequin seems to be helping his arthritis, but I'm thinking of switching him to Dasuquin when I have to order more.

The B12 we have is the red color that Sharky was talking about.
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