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Rabies Vaccine-Feline Tumors Study

post #1 of 14
Thread Starter 
Research Updates: Investigating the Impact of Vaccine Administration Site Changes in Cats DVM360 October 1, 2009 by Erika Meler and Barrak Pressler http://veterinarymedicine.dvm360.com.../detail/632167

"The study's results also imply that the rabies vaccine may be the most oncogenic. After 1996, when specific locations could be associated with specific vaccines, the right rear limb, which is the recommended site of rabies vaccination, was the most common site of injection-site sarcomas. "


Oncogenic: Causing or tending to cause the formation and development of tumors
post #2 of 14
Reading the entire article is informative - and, since we have rabies in my area, still getting the shot, per advice of my vet (and her own indoor cats get the shot as well).
post #3 of 14
Personally, all of my babies get vaccinated (just rabies and FVRCP). I have weighed the risks and feel that's the best decision for my peace of mind and my kitties health. I am in no way claiming vaccination cannot cause injection site sarcomas!

BUT, almost every single pathology report we get back on masses on the hip or shoulder areas always has the "Possibly due to injections" line somewhere in it. Stress on the word POSSIBLY. But of course when we give the clients a copy of the path report that's the only thing they see and suddenly they're telling everybody their cat has an inject site sarcoma and to never vaccinate your cats. Just remember every story has two sides....
post #4 of 14
Important info in this article

http://www.2ndchance.info/fibrosarcoma.htm
post #5 of 14
Thread Starter 
The American Veterinary Medical Association actually established a Vaccine-Associated Feline Sarcoma Task Force in 1996 "in response to the increased incidence of soft tissue sarcomas occurring at vaccination sites." This link will take you to the AVMA website http://www.avma.org/vafstf/default.asp.

This link http://www.avma.org/vafstf/vafstf01.asp will take you to the 2001
Report of the Vaccine-Associated Feline Sarcoma Task Force, which states that: "Most killed-virus vaccines contain adjuvants to enhance the immune response, and injection of some killed-virus vaccines has been shown to result in inflammatory granulomas in cats.2 Some of these inflammatory granulomas to progress to sarcomas.3"

Rabies vaccines are killed, adjuvanted vaccines.
post #6 of 14
Quote:
Originally Posted by Kris Christine View Post
Rabies vaccines are killed, adjuvanted vaccines.
Look up Purevax, it's non-adjuvanted. There are also intranasal vaccine options.
post #7 of 14
Quote:
Originally posted by Kris Christine
Rabies vaccines are killed, adjuvanted vaccines.
Kris, PUREVAX is a safe adjuvant-free rabies vaccine.


http://www.geocities.com/~kremersark/purevax.html

Quote:
PUREVAX is a highly purified rabies vaccine just for cats and kittens. The unique science behind PUREVAX has identified the natural components that produce rabies immunity, so there's no need for chemical additives called adjuvant's. That's what makes PUREVAX so pure.
Unlike other vaccines, PUREVAX doesn't use chemical adjuvants or the whole rabies virus to protect your cat. Through advanced technology, it introduces only those proteins needed for rabies protection. And, PUREVAX eliminates the chronic injection site inflammation that can be associated with rabies vaccination. It is the only rabies vaccine approved for use in kittens as young as 8 weeks old.

PUREVAX completely eliminates the need for chemical adjuvants in feline vaccines, virtually eliminating the chronic injection site inflammation and avoiding other adjuvant-related reactions.

PUREVAX purity is achieved through advanced technology that produces a proven protective response in cats by introducing only those proteins needed for rabies protection. The whole rabies virus is never introduced.
From another article:

http://www.thecatpracticepc.com/rabies.htm


Quote:
The Merial PUREVAX® feline rabies vaccine is currently the safest feline rabies vaccines on the market.
This is because the PureVax™ vaccine does not contain adjuvants, as all other rabies vaccines do. Adjuvants are substances added to a killed vaccine to increase the body’s immune response to the vaccine (since the virus is killed and doesn’t stimulate an adequate response on its own).

Adjuvants have been linked to vaccine-related fibrosarcomas in cats (i.e. cancerous tumors at the site of the vaccine). Although this is rare (about 1 in 10,000 cats), it is a major concern of veterinarians since this type cancer is extremely malignant, fast-growing, and will spread quickly to other parts of the body.

Adjuvants contain several different substances to enhance the immune response, including aluminum salts. Fibrosarcomas have been vigorously tested and studied by scientists – they found that aluminum was present in up to 42% of the cells in the tumor itself. This suggests that adjuvants may play a big role in vaccine-related fibrosarcomas.
post #8 of 14
Thread Starter 
Yes, felines are fortunate to have a non-adjuvanted rabies vaccine.
post #9 of 14
My vet uses Purevax only. They have to get it every year instead of every three, but its worth it to me.
post #10 of 14
Thread Starter 
Quote:
Originally Posted by AlleyGirl View Post
My vet uses Purevax only. They have to get it every year instead of every three, but its worth it to me.

Personally, that is the choice I would make as the adjuvants in the vaccine concern me more than the antigen.

"The World Health Organization (WHO) in 1999 classified veterinary vaccine adjuvants as Class III/IV carcinogens with Class IV being the highest risk," IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Volume 74, World Health Organization, International Agency for Research on Cancer, Feb. 23-Mar. 2, 1999, p. 24, 305, 310.
post #11 of 14
Purevax NOW has a 3 yr rabies that is non-adjuvanted
post #12 of 14
Thread Starter 
As far as I know, it has not received a USDA license yet.
post #13 of 14
Quote:
Originally Posted by sharky View Post
Purevax NOW has a 3 yr rabies that is non-adjuvanted
That's excellent. Maybe my vet will have it by the time my boys are due next year.
post #14 of 14
Quote:
Originally Posted by Kris Christine View Post
As far as I know, it has not received a USDA license yet.
That was my understanding as well. Currently my vet only has the 1-yr Purevax.
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