This very well could be the case. You may want to try another cleaner. I am not familar with the Nature's Way enzyme cleaner. Many of the enzyme cleaners in the pet stores do nothing but mask the smell. And this one may be one of them. My opinion and my opinion only is I don't know why everyone raves about Nature's Miracle. Yes, it does an okay job sometimes on linoleum but I found it does not do a good job on carpet, sofa or anything else. It just masked the smell for my situation (even after soaking it 3-4 times and spending alot of money on a masked smell). If you search around on the site many people have given cheap natural cleaners that have worked very well for them. But I would recommend those other two I posted earlier.Is it possible that the reason she wants to go on the floor near the same spot because she can still smell it even after using the enzyme cleaner?
Many people use Dr. Elsey's cat attract to get their cats using the litterbox again. You could put it in the box downstairs and after a while put it in the box upstairs as well.
I know you have said that the vet checked a stool sample but have you taken her to the vet to be checked for constipation/blockage or enlarged anal glands? I think at this point you have nothing to lose to check this out. She also could be getting constipated from the different medications. |This does happen. She also may associate the pain with pooping with the litterbox so she is searching for somewhere softer to poop on. I know she sometimes poops in the litterbox and sometimes doesn't. My cat did this too when she was constipated/blocked as well. Many people have told me that their cat was pooping outside of the box for no aparent reason and after all the tests - the full blood work up finally confirmed an illness. Also people have said their cat was pooping outside of the litterbox b/c the cat had a UTI, crystals, stones, etc.