I'm moving cross country too - it must be that time of year.
I'm taking my 4 cats in separate carriers in the rental truck with me. Mover muscle arrives at 10 a.m. on the 5th to pack my rental truck, so kits go into carriers just before they arrive.
Then after truck is packed, cats get put in front seat of the rental truck along with me and my dad (who is crazy enough to have volunteered to drive me cross-country and who has been warned about one very loud alpha male bengal) then off we go on a 14-16 hour drive, straight through to my new home 820 miles away from the only place I've ever known.
Scary stuff, yes, but exciting, too!
To make it up to my kits for the upheaval and horribly long truck ride, in the new place they will have a brandy-new, 6 foot long by 8.6 feet tall by 2 feet deep cat condo/jungle-gym with two floor-to-ceiling poles, tons of platforms and hammocks and hidey holes for them to explore and claim as their own.
I'm hoping it eases their stress. I decided not to do an overnight stay, as I think that going straight through will be the best choice for all concerned in my case.
I have packed and ready for the truck: Puppy pads for the crates, garbage bags, paper towels, unscented baby wipes. I will also have small bowls for offering them each a taste of wet food and/or water. I expect potential crate accidents, so each will be in a harness with a leash attached for keeping them safe when I am changing out messes.
I'm not bothering with sedatives, as they will settle down after the first couple of hours, and I don't want to risk them having a reaction. Instead, I'll give them some calming stuff that gets added to the water - it's specific for relieving travel stress. (I hope they don't get runny poopies from it, that'll stink, pun intended!)
Once they are in the carriers, they are stressed to the max, so my intention is to get us packed and into the truck and on the road ASAP. The sooner we are driving, the sooner we'll get there. A new home. Where my cats are.