Hi all- It's been a while since I posted but I can really use some advice. Mertle is 15 and has inflammatory bowel disease. Background: She has lived with diarrhea and vomiting for one year-and the diagnosis was pretty much IBD (I would not allow the vet to biopsy since I wouldn't have put her on chemo if she had cancer, so that's why I say pretty much). I recently took her to a new vet and it turns out he is also pretty sure it is IBD-he didn't feel anything bad in her belly and one level of her white blood count was higher than normal indicating what the vet feels is an infection in her intestines due to the IBD. Comprehensive blood workup done last week shows no kidney/liver issues, urine and fecal are both ok. I have tried all different foods including duck and venison and she will starve herself for days. I can't allow that as she is dropping weight - she is only 7.5 lbs down from 8.9 last year down from 10 the year before. Here's where all my problems really begin: The vet put her on prednisolone - 5mg 2x/day. After about 4 days-when the vet said the meds would kick in-she shoved herself under my husband's shoe rack in the closet and wouldn't come out. When she did, she layed in the litter box. Her pupils were dialated as big as her eyes and she was listless. She didn't poop for 24 hours and when she did, she basically exploded wet stool up to my walls! and then vomited all over the bathroom. This was 10 times worse than any bad IBD spell. I called the vet and they still recommended I keep her on the meds which I thought was cruel. The cure seemed worse than the disease. I can get pepcid in her wet food and she'll sometimes eat it. I have read other posts where people recommend a raw diet and some other different foods. The issue is she is just not getting nutrients from her food into her body so the weight loss continues as does the diarrhea and vomiting. I am less concerned about "why" this is happening as to how I can give her a quality of life she can enjoy and not wither away. She runs and plays and has good days and bad days. I hate that she jerks her belly in the litter box just to squeeze out some runny mess yet she is in no way ready to be put down. I have a 4 year old boy cat that is now beating up on her to become the alpha-it is not a violent, everyday thing but it also shows me that we all see she is getting weaker. Has anyone's cat had such a wild reaction from prednisolone? Do I try it again? Does anyone know of any way I can get nutrients to stay in her and get some weight back on her without the steroids? I plan to call the vet but since the vet seems to be guessing a bit as to what will work, I'd like to go into the conversation with recommendations and see what he thinks. Any help is appreciated.