Zoey had a deworming pill once...not sure which one. I was specifically told not to crush it up in food, as it has a very bitter taste.
This is how we've done it: If your kitten is a fighter, see if you can get someone to help you. Wrap him/her in a towel and hold her. The other can tilt the head back (jaw should go slack), open the mouth, and put the pill as far back in the mouth you can get it (careful not to get bitten). Then close her mouth and hold it closed until she swallows. Then, try again, because she'll likely spit it out.