Hey, we picked up our kitty Ares from a breeder who lived 1000 miles away. As it turned out, he is an awesome and well-adjusted cat, which definetely helped, but here are a few things we did:
He wasn't freaked out by the carrier, since we sent it to the breeder months before, so that the carrier sat out was played in by Ares and his littermates. (If your cat is not used to or not crazy about his carrier, I would recommend spraying it with Feliway, and leaving it out in a play area. Place a few favorite toys/treats in there to entice him into the carrier and to create positive associations.) You might also want to try a few short car rides with him in the carrier to get him used to it.
We also placed a disposable litter box with litter into the trunk, along with a scoop. We stopped every 2 hours to give him food, water, and a litterbox break. (When doing this, make sure all of the car doors are closed and the windows are shut.) We ensured he had a toy or 2 in the carrier, and rotated them out with different toys for interest. Not knowing how he would react to the trip, we purchased Rescue Remedy (which is supposed to calm cats) which can be rubbed on the ear, but he was super relaxed, so it was unecessary.
You didn't mention whether you would stay overnight in a hotel. If you are planning to, I would recommend booking in advance, as finding a hotel that takes pets can be difficult.
If you do stay in a hotel, I would take his litter box, toys, etc up to the room, and spray some Feliway in prominent areas of the room. Then bring him up, and once you let him out of the carrier, be present to see how he reacts to the new surroundings. If you go out, I would put kitty back in the carrier, and also make sure you put the "Do Not Disturb" sign on the door, so that the hotel staff will knock before entering the room. Hope this helps!
Becca, Ares, and little boy who hasn't been named yethttp://i196.photobucket.com/albums/a...ow2/Ares39.jpghttp://i196.photobucket.com/albums/a...rrow2/boy1.jpg