I prefer frontline plus to regular frontline or advantage. For my dogs- i use Revolution (it combines flea & tick preventive and heartworm prevenative.) I also use Frontline Plus for dogs on the ones at the shelter and LOVE it. Advantage just simply doesn't cut it around here as in the south we have a HUGE flea and tick issue right now. I prefer frontline plus for cats because it works well on both. If you're treating for JUST fleas though- you might consider trying Capstar.
All of my furbabies get prevenative even though they're indoors only- because it only takes a moment of the dogs being outisde to potty to track something in....or me tracking in something from the shelter with me when i come home from work. At the shelter....i've seen the best effects come from using Frontline Plus as far as dogs go- we're talking about dogs that come in with massive infestations of both fleas and ticks. Same for cats.
If you are JUST using advantage though- stop buying the feline advantage and get the Advantage for small dogs under 10lbs. The formula is identical, the packaging is the only difference. Instead of using an entire tube- only apply four drops to the back of each kittys neck. It will protect them against fleas
(not ticks though!) this does not work however for other brands/formulas so only do that with regular advantage.
In a pinch or on small puppies/kittens the best thing to use is just some Dawn dish soap and a flea comb. After the bath then it's safe to use a little bit of Adams flea and tick spray (that stuff works pretty good but isn't the best- on small animals however, it's the safest thing next to just flea combing!)