This has been announced on one of our Ragdoll lists, and permission has been given to crosspost. This is so important for the Ragdoll breeders.Hi Everyone,
We are happy to announce that Dr Meurs has found and identified a mutation that causes HCM in Ragdolls. We can now begin testing for this mutation in our cats.
Dr Meurs was hoping to make this announcement herself, but the in scientific world, she can't say anything until her work is 'peer reviewed' and published in a Scientific Journal. It has now been reviewed, and will be in a publication that is due out June 15th. After that time, she will make her formal announcement. Up till this point we have been asked to keep the news kind of quiet until the big announcement is out. However, with it being posted on the website of the University word has been getting out. So we decided to go ahead and announce it, and hope people will understand that Dr Meurs can't comment on it yet.
The lack of formal announcement won't make any difference to you though, as the test can be done without the announcement from her. We just want you to understand where this is coming from. On the website <http://testyourcat.com> are the directions for obtaining the swabs to do the test with, and how to send in blood (recommended for nursing kittens). The prices for the test are posted also, along with FAQ's that you should take time to read.
Ester, Dr Meur's assistant, has agreed to come on The Open Forum List to answer questions that may not be covered on the FAQ. She said she will try to read the list a minimum of once a week, so we have to be patient with our questions. We (the committee) will try to answer any questions that come up in the meantime, if we have the answers.
There are three possible outcomes for the test. One is negative. This is the best. The other two are Positive/Hetrozygous (Pos/Het) meaning that the cat is carrying one mutation for HCM, and Positive/Homozygous (Pos/Homo) meaning the cat is carrying two copies. As of now, we do not have any statistics as to whether one mutation will not cause HCM, or cause it later in life, etc. That will come when we have enough cats tested so we can gather that info. We think we can agree that it is better for us if the cat only has one mutation rather than two, because it can be bred out in only one generation, but that's all we can say about it at this time.
There are two important things Ester would like to pass on. One is, that the AVERAGE turn around time for the tests is 2 weeks, but that is not written in stone. Sometimes there is a mistake in cutting out the DNA for the test, or something else goes wrong, and they have to retest the swab. The second thing she says is that it is important to remember is that this test is ONE STEP in a decision on which cats to keep and which cats not to keep. DO NOT DO ANYTHING RASH when you get your results.
In the Maine Coon, the statistics show that about 35% of the Maine Coons have the mutation, with just 4% having two copies. This is too large of a number for the breed to cut out all cats with one mutation. The recommendation is to breed cats that are Pos/Het with a Negative cat, and keep a replacement that tests negative. To simply wipe out one third of the breed could do more harm than good. Ester will talk more about this when she gets on the list.
This is wonderful news for all of us, and our hard work raising money for this research is paying off. Congratulations everyone. Great Job. However, this doesn't mean we can stop the research now. There could be other mutations out there. This is a good start.
Hopefully all of us will work together, without finger pointing, to eliminate this mutation from our breed. It will be a long and hard path to this end, but it will be worth it. So let's all work on getting our cats tested, and trying to rid our breed of this particular problem as quickly, but as safely as we can. Up until now, trying to find out which cats have HCM and which don't, has been quess work. Now we have a real tool to work with. Remember that we will probably all be affected by the findings, so let's have patience and treat each other with kindness and compassion, so we can do what is best for the breed.
One more thing. Since there will now be a big rush to have cats tested, we are suggesting that only current breeders and litters be tested at this time. No pets or alters should be done until we get the majority of breeder results back. There will be time for pets and alters later.
Please pass this on to other lists that you may be on. It's important for everyone to know about this.
Thanks everyone,
Your HCM Fundraising Committee
For those who would like to help with Ragdoll research, please go to www.ragdollresearch.org. They are gearing up for the 3rd annual HCM auction, and it always attracts many wonderful gifts for everyone, and a great way to find Christmas gifts, while helping the Ragdoll breed. You can also give personal donations as well.
I will be one of the first in line to have all of our breeding cats DNA tested and once this becomes a reality so should all Ragdoll breeders to eliminate this horrible heart disease.
Go Dr. Meurs!!
We are happy to announce that Dr Meurs has found and identified a mutation that causes HCM in Ragdolls. We can now begin testing for this mutation in our cats.
Dr Meurs was hoping to make this announcement herself, but the in scientific world, she can't say anything until her work is 'peer reviewed' and published in a Scientific Journal. It has now been reviewed, and will be in a publication that is due out June 15th. After that time, she will make her formal announcement. Up till this point we have been asked to keep the news kind of quiet until the big announcement is out. However, with it being posted on the website of the University word has been getting out. So we decided to go ahead and announce it, and hope people will understand that Dr Meurs can't comment on it yet.
The lack of formal announcement won't make any difference to you though, as the test can be done without the announcement from her. We just want you to understand where this is coming from. On the website <http://testyourcat.com> are the directions for obtaining the swabs to do the test with, and how to send in blood (recommended for nursing kittens). The prices for the test are posted also, along with FAQ's that you should take time to read.
Ester, Dr Meur's assistant, has agreed to come on The Open Forum List to answer questions that may not be covered on the FAQ. She said she will try to read the list a minimum of once a week, so we have to be patient with our questions. We (the committee) will try to answer any questions that come up in the meantime, if we have the answers.
There are three possible outcomes for the test. One is negative. This is the best. The other two are Positive/Hetrozygous (Pos/Het) meaning that the cat is carrying one mutation for HCM, and Positive/Homozygous (Pos/Homo) meaning the cat is carrying two copies. As of now, we do not have any statistics as to whether one mutation will not cause HCM, or cause it later in life, etc. That will come when we have enough cats tested so we can gather that info. We think we can agree that it is better for us if the cat only has one mutation rather than two, because it can be bred out in only one generation, but that's all we can say about it at this time.
There are two important things Ester would like to pass on. One is, that the AVERAGE turn around time for the tests is 2 weeks, but that is not written in stone. Sometimes there is a mistake in cutting out the DNA for the test, or something else goes wrong, and they have to retest the swab. The second thing she says is that it is important to remember is that this test is ONE STEP in a decision on which cats to keep and which cats not to keep. DO NOT DO ANYTHING RASH when you get your results.
In the Maine Coon, the statistics show that about 35% of the Maine Coons have the mutation, with just 4% having two copies. This is too large of a number for the breed to cut out all cats with one mutation. The recommendation is to breed cats that are Pos/Het with a Negative cat, and keep a replacement that tests negative. To simply wipe out one third of the breed could do more harm than good. Ester will talk more about this when she gets on the list.
This is wonderful news for all of us, and our hard work raising money for this research is paying off. Congratulations everyone. Great Job. However, this doesn't mean we can stop the research now. There could be other mutations out there. This is a good start.
Hopefully all of us will work together, without finger pointing, to eliminate this mutation from our breed. It will be a long and hard path to this end, but it will be worth it. So let's all work on getting our cats tested, and trying to rid our breed of this particular problem as quickly, but as safely as we can. Up until now, trying to find out which cats have HCM and which don't, has been quess work. Now we have a real tool to work with. Remember that we will probably all be affected by the findings, so let's have patience and treat each other with kindness and compassion, so we can do what is best for the breed.
One more thing. Since there will now be a big rush to have cats tested, we are suggesting that only current breeders and litters be tested at this time. No pets or alters should be done until we get the majority of breeder results back. There will be time for pets and alters later.
Please pass this on to other lists that you may be on. It's important for everyone to know about this.
Thanks everyone,
Your HCM Fundraising Committee
For those who would like to help with Ragdoll research, please go to www.ragdollresearch.org. They are gearing up for the 3rd annual HCM auction, and it always attracts many wonderful gifts for everyone, and a great way to find Christmas gifts, while helping the Ragdoll breed. You can also give personal donations as well.
I will be one of the first in line to have all of our breeding cats DNA tested and once this becomes a reality so should all Ragdoll breeders to eliminate this horrible heart disease.
Go Dr. Meurs!!