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Thanks for the replies. Just an update that after a few days she seems to have adjusted very well to the prednisone and is sleeping well again. 

Hi everyone, My beloved 17 year old flame point siamese recently developed a growth/swollen lymph node in her armpit that's so troublesome it's causing her to drag her front leg. She's doing well otherwise, eating well and pretty good attitude, purring, etc, but definitely worn out and sleeping...