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Very quick update: Michelle is much doing better on the Prednisolone.  No more vomiting, moving around a lot more, and the vet is able to confirm she's gaining weight.  Vet said on our visit it was too soon for a blood test, but will follow up with one on the 28th.  She would like to keep...

Oops, forgot to include the link to the EU report in the above post: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002464/WC500133226.pdf

About the vet:  I'm meeting w/ her & Michelle on Wednesday.  I'll bring in w/ me all the evidence I can find on pros vs cons & safety record.  I'm now very much hoping the drug company responds with documents from their various animal & human studies.

LDG, you are right.  It's a matter of evaluating it on the basis of potential outcomes vs. risks.  Here's the reply from Defra (UK Home Office): So, key here is now to best weigh risks, benefits, safety of Pred vs. new drug, or determine if they may be used safely in tandem.  If the new drug...

The part of the cascade that's confusing me: "A veterinary medicine authorised in the UK for use in another animal species or for a different condition in the same species." It could be argued here that Prednisolone, while no treatment specifically for the disease of Myelofibrosis, is...

I've now e-mailed the UK Home Office (defra) for advice.  I've found additional links about the prescribing cascade veterinarians here must adhere to: http://www.rcvs.org.uk/advice-and-guidance/code-of-professional-conduct-for-veterinary-surgeons/supporting-guidance/veterinary-medicines/...

White Shadow, is that a US vet website?  Not sure she'd belong, because we're in the UK (I'm an American). I've asked the Vet about Jakafi (US)/Jakavi (UK), and she's advised we need to make sure it's licensed for use in animals, not just in humans.   There's something here called "The Drugs...

Thanks,  LDG, I've seen stem cell and Jakafi (Ruxolitinib) mentioned in the research.   Pity about the stem cells, there might have been potential there to reverse the disease. The Jakafi looks promising: Ruxolitinib Boosts Survival In Patients With Myelofibrosis...

LDG, yes, the results came back yesterday.  But vet didn't call until today, as she needed to double-triple-check the diagnosis with the experts.  It's Myelofibrosis and we've just started our first 5mg dose of Prednisolone (snuck into a piece of chicken breast), a steroid to slow the immune...

I've gone to the vet and clarified.  She's only received half the test results back from the lab.  She's still waiting for the other half, and advises we shouldn't sit down to discuss and intepret until she's gotten all the results back from the lab. She's hoping (fingers crossed) the other...

Thanks LDG for the links.  As per the Corrected Reticulocyte calculation provided on the Merck website: the observed %Retic on Michelle's blood test, 2.4%, equates to roughly 0.56% when corrected for anemia (2.4*(8.8/37.5)).    As this is below <1%, looks like it doesn't indicate regeneration...

Dan, Wow, that's awful it took so long to get a diagnosis.  And 4 different vets!  I hope Kinney is on the permanent mend now. 

Thanks!  So glad I found you guys

White Shadow, You are right!  RETIC is 33.0 K/uL out of a range of 3.0-50.0.  So it's very high within the normal range.   The body is releasing immature red blood cells too quickly into the blood, in order to compensate for lack of mature RBCs.  I now wonder why we're talking in the vet office...

Ah, did not know normal was different for different labs! HCT normal range on the lab blood results was defined as 30.0-45.0.  As of yet, no one has discussed blood transfusions, nor any drugs/treatment.  I think the vet is waiting for the bone marrow biopsy lab results before taking any...

Hello.  My 3 year old domestic shorthair Michelle (in my avatar photo) was losing weight and in general seemed more lethargic than her sister.    Michelle is eating extremely heartily (as usual), drinking OK, cleaning herself well, still making regular trips to litter tray, etc.  Everything...

Hello fellow cat moms & dads, I have two cats, both 3 years old.  Rosie & Michelle (Michelle is in my avatar photo).  I adoped them (or they adopted me) from the local animal shelter.  Their mom was a feral and they were raised for the first 12 weeks of their life, along with their...