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I know there have been a number of threads about hissing, aggressive cats. Many have a idea of the cause. I have none. I live in a quiet home with my 92 year old father. We have no children, dogs or other cats around. She hisses whenever I try to handle her in any way. Forget cutting her claws...

I have a new kitten with whom I probably play with a hour a day. I never use my hands in play but always utilize a toy. When he scratches or bites me, I stop playing and redirect his play back to the toy. Sometimes I stop altogether. When I stop, he proceeds to bite my toes or ankle to reengage...