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It can upset their stomach.  I would do a little more each day.  1/4, 1/2, 3/4. 

About six months ago we got a new female cat and she is a bundle of energy.  She and my 13 year old boy usually ignore each other, but she does like to tap him on the head to get him to play with her which can end up in some pawing the air or him just ignoring the tap.  They never fight and...

Well of course there was no hissing, they were eating treats .  Keep doing it so they get more positive associations with each other.  Also remember to keep rubbing their faces with the same sock to intermingle their scents.

You may need to reintroduce them as if one was a new cat. This is an summary of a great detailed method, I read in this book. http://www.amazon.com/The-Cat-Whisperer-Do-ebook/dp/B004HZYBFE Make sure that you get them used to each other's scent before they even glance at each other.  Take two...

Dont forget to continuously mingle their scents with a clean sock, then a brush on their face.

Sorry to spam this on several threads but it really worked for me. This is an summary of a great detailed method, I read in this book. http://www.amazon.com/The-Cat-Whisperer-Do-ebook/dp/B004HZYBFE Make sure that you get them used to each other's scent before they even glance at each other...

This is an summary of a great detailed method, I read in this book. http://www.amazon.com/The-Cat-Whisperer-Do-ebook/dp/B004HZYBFE Make sure that you get them used to each other's scent before they even glance at each other.  Take two clean thin socks and and rub one on the face  of each cat...

This is an summary of a great detailed method, I read in this book. Make sure that you get them used to each other's scent before they even glance at each other.  Take two clean thin socks and and rub one on the face of each cat.  Let them sniff eachother's sock and if there is no adverse...

They are for anxiety and aggressiveness.  They contain pheromones that calm cats.  Anxiety can cause scratching and urine marking, but those are just symptoms.  It can't hurt to try them.

Have you tried a pheromone difuser like Feliway and/or a pheromone collar like Sentry Good Behavior?

How long have they been living together? Could the older cat be sick?

You need to call your vet right away.

Have you considered getting the medicine compounded by a pharmacy into a liquid or ear cream?  If she won't eat, I would try fancy feast classic salmon.  I had a very sick cat and that was all she would eat.

I have read that freeze dried probiotics are just as effective.  Is this true.  Are they at least close?  I am also worried about stomach acid destroying the bacteria before it reaches the intestine. I am considering Mercola Complete probiotics for pets.  Thanks!

Just an update. I had the three liquids changed to chews and she eats them as treats. So now instead of 2 squirts of liquid in the morning and 3 squirts + the pill at night, all we have to give her is the pill at night. This has made her a lot more comfortable and she is coming out a lot more...

My incredibly affectionate cat Lilly now hides all day because she is afraid of taking her heart medicine. 3 of her medications are liquid that we squirt down her throat, but the last is Plavix, which can't be liquified. It is a really struggle to get the pill down every night and she runs off...